Even if you assume all of the 1-seeds beat the 16-seeds in Round One, your chances of picking a perfect bracket are about 1 in 576 quadrillion.
To be exact, it's 1 in 576,460,752,303,423,488.
That's not only smaller than your odds of winning the lottery, it's smaller than your odds of winning the lottery twice.
Depending on the jackpot size, it's easier to make $1 billion by winning the Mega Millions two times than by winning Buffett's bracket challenge.
The odds of winning the Mega Millions are 1 in 259 million.
Therefore, the odds of winning the Mega Millions twice are 1 in 14.9 quadrillion (1 in 14,907,351,000,000,000, exactly).
Those are long odds, but it's actually WAY better than your chances of picking a perfect bracket.
You're 38 times more likely to win the Mega Millions twice than to win $1 billion from Buffett.
Consequently, Tuesday night's Mega Millions jackpot is up to $400 million.