"Today, after 4 years of user/business momentum in India & the region, I'm sharing my intention to move on to new opportunities, same mission," Jaitly tweeted.
Jaitly drove strategic partnerships with the news, government, entertainment, sports, TV industries, and others in the mass and emerging media landscape.
Jaitly was the Vice President of Twitter's Asia Pacific and Middle East business. He will leave the company at the end of November after four years of service.
Jaitly joined Twitter from the Knight Foundation, where he led investments in technology, media, and digital tools.
In a bid to realign its future goals and cut costs, Twitter recently reduced nine per cent of its workforce (nearly 350 people) globally.
"We have a clear plan, and we are making the necessary changes to ensure Twitter is positioned for long-term growth," CEO Jack Dorsey said in a statement earlier.
Last year, Twitter cut 300 jobs after Dorsey took over as CEO full-time.
Twitter had 3,860 employees as of June 30 this year and paid out $168 million in stock-based compensation in the second quarter.
Earlier this month, Twitter's last potential buyer
Salesforce CEO