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<ul><li>Google Doodle is celebrating the Indian bollywood icon <keyword id="16975" type="PERSON" weightage="20" keywordseo="Zohra-Sehgal">Zohra Sehgal</keyword> today for her shattering the glass ceiling of Indian cinema back in 1946.</li><li>The movie was Indian cinema’s first film to gain international acclaim. </li><li>Sehgal also acted opposite the first <keyword id="492147" type="ENTERTAINMENT" weightage="20" keywordseo="Doctor-Who">Doctor Who</keyword>, <keyword id="10019192" type="UNKNOWN" weightage="20" keywordseo="william-hartnell">William Hartnell</keyword>.</li></ul>Most millennials remember Zohra Sehgal as their favourite on-screen dadi in films like <keyword id="37921" type="ENTERTAINMENT" weightage="20" keywordseo="Kabhi-Khushi-Kabhi-Gham">Kabhi Khushi Kabhi Gham</keyword>, <keyword id="37737" type="ENTERTAINMENT" weightage="20" keywordseo="Dil-Se">Dil Se</keyword>, and Veer Zaara. But before she was the grandmother that we all know and love, Sehgal already had a long series of wins under her belt. This includes a brief stint in the original BBC series Doctor Who and acting in the first Indian movie — <keyword id="62426" type="ENTERTAINMENT" weightage="20" keywordseo="Neecha-Nagar">Neecha Nagar</keyword> — that was met with international acclaim. <div type="image" title="ZohraSehgal_DoctorWho_TardisFandom_edited" msid="78377871" hostid="261" caption="&amp;lt;p&amp;gt;Zohra Sehgal in Doctor Who&amp;lt;/p&amp;gt;"></div> Google Doodle today is celebrating Sahibzaadi Begum Zohra Mumtazullah Khan for shattering the glass ceiling of Indian cinema back in 1946. Sehgal’s was cast in Chetan Anand’s Neecha Nagar and the movie made it onto the screens at the Cannes Film Festival. It was Indian cinema’s first international critical success. <div type="image" title="neechanagat" msid="78377894" hostid="261" caption="&amp;lt;p&amp;gt;The poster for &amp;lt;em&amp;gt;Neecha Nagar&amp;lt;/em&amp;gt;&amp;lt;/p&amp;gt;"></div> Zohra Sehgal travelled the world before settling in India Sehgal was born in Uttar Pradesh’s Saharanpur. And her official title is actually Sahibzaadi Begum Zohra Mumtazullah Khan — a Rohilla Pathan of the Rampur nobility. In her early 20s, Sehgal left for Germany to study ballet, after which she travelled the world with legendary icon Uday Shankar for a decade. <div type="image" title="Uday_Shankar_Ballet_Troupe,_ca_(1935-37)" msid="78377906" hostid="261" caption="&amp;lt;p&amp;gt;The Uday Shankar Ballet Troupe. Also seen at the bottom left Zohra Segal, who joined in August 1935, and toured with Uday Shankar till he returned to India, 1938.&amp;lt;/p&amp;gt;"></div> In 1945, she returned to India to join the Prithvi Theatre and moved across the country with the troupe for shows. It was during this time that she signed onto Neecha Nagar. A little over a decade later, Sehgal moved to New Delhi as the newly appointed director of the Natya Academy. Acting with the very first Doctor Who Her stint at the academy was a short one, from 1959 to 1962, when she moved to London, and we saw her on the international stage across the first Doctor Who, William Hartnell. She posed as Sheyrah in season two of the series in the episode arc called <a href="http://www.bbc.co.uk/doctorwho/classic/photonovels/crusade/two/index.html">The Crusade</a>. She also had a small role in the 1964 story Marco Polo. She only returned to India in the 1990s, where she continued to act and went on to win the Padma Shri in 1998 and the Padma Bhushan in 2002. Sehgal was 102 when she passed in 2014. SEE ALSO: <a href="https://www.businessinsider.in/stock-market/news/top-stocks-to-watch-infosys-central-bank-of-india-dhfl-anuh-pharma-shalby-balaji-telefilms-and-others/articleshow/78376167.cms">Top stocks to watch— Infosys, Central Bank of India, DHFL, Anuh Pharma, Shalby, Balaji Telefilms and others</a> <a href="https://www.businessinsider.in/finance/news/rbi-postpones-monetary-policy-meeting-new-dates-to-be-announced-soon/articleshow/78361698.cms">RBI postpones Monetary Policy meeting as the hunt for three new MPC members continues</a> <a href="https://www.businessinsider.in/defense/news/rajnath-singh-releases-indias-new-defence-acquisition-procedure-amid-india-china-border-dispute/articleshow/78362908.cms">Rajnath Singh releases India's new Defence Acquisition Procedure amid India-China border dispute</a>

Google Doodle celebrates Zohra Sehgal — Everyone's favourite dadi, an Indian royal and Doctor Who star

<div class="KonaFilter image-container float_right"><div class="image on-image"></div></div>Right now, a naturally-produced substance called rapamycin is being described as the source of potentially one of the most transformative medicines in the world, one that has a small but not impossible chance to become the first drug to successfully slow the effects of aging - "the ultimate preventative medicine," as Matt Kaeberlein, a prominent researcher who studies aging at the University of Washington, <a href="http://www.bloomberg.com/news/features/2015-02-12/does-a-real-anti-aging-pill-already-exist-">described it to Bloomberg Businessweek</a>.But - as told in <a href="http://www.bloomberg.com/news/features/2015-02-12/does-a-real-anti-aging-pill-already-exist-">a wide-ranging Bloomberg Businessweek cover story</a> - the only known samples of it would have been destroyed if it weren't for a researcher who was just too intrigued by rapamycin's potential to let that happen.This substance, produced by a bacteria, has already been used to develop treatments for kidney, lung, and breast cancers (Novartis <a href="http://www.novartis.com/downloads/investors/reports/novartis-annual-report-2013-en.pdf">earned more than $1 billion</a> from these treatments in 2013), among many other uses. Yet it wouldn't - couldn't - be the subject of such excited pronouncements, if Dr. Suren Sehgal had obeyed his bosses at Ayerst Laboratories.In 1983, <a href="http://www.sehgal.net/surenshistory.htm">Ayerst was closing</a> their Montreal lab and decided that everything that didn't have a defined productive use yet should be destroyed. Almost a decade before that, Sehgal had found a rare bacteria in some dirt a 1964 Canadian research team had scraped from underneath a moai, one of the massive stone heads on Easter Island. Sehgal discovered that the bacteria, Streptomyces hygroscopicus, produced a powerful anti-fungal compound. He sent a sample to the National Cancer Institute, <a href="http://www.businessinsider.com/how-climate-change-could-destroy-medicine-2014-4">which has a branch dedicated</a> towards investigating the potentially powerful biological agents derived from the natural world.Sehgal gave the compound the moniker rapamycin, reminiscent of the native name for the island it came from, Rapa Nui.But Ayerst didn't want to pursue the rapamycin investigation. Sehgal kept experimenting with it on the side - he once used it to create an ointment that cured a fungal skin infection for a neighbor. "It was probably illegal," his son Ajai Sehgal <a href="http://www.bloomberg.com/news/features/2015-02-12/does-a-real-anti-aging-pill-already-exist-">tells Bloomberg Businessweek</a>, but it worked.Yet it fell onto the list of "nonviable" compounds that were slated for destruction when Ayerst shuttered their Montreal operation.And even though Sehgal was a dedicated employee (one of the only ones to keep his job after they closed the lab), he couldn't bear destroying this thing he was so excited about.So he took a rogue step. Instead of destroying the rapamycin, he took a few glass vials of the bacteria home and stashed them in his freezer. As Bloomberg Businessweek reports, he wrapped them in plastic and stuck them beside some ice cream, writing a note that said "DON'T EAT!"Don't eat, indeed.He and his family moved to Princeton, N.J., to continue working for Ayerst in their lab there.In 1987, Ayerst was bought by another pharmaceutical company, Wyeth - and they were amenable to letting Sehgal continue his research. When Sehgal discovered that rapamycin also suppressed the immune system, he and Wyeth realized it would help people receiving an organ transplant, by making their bodies less likely to reject it. That usage was approved by the FDA in 1999.But the other thing that's making waves right now is the idea that rapamycin could actually be the source of an anti-aging pill that could change the basic course of human lives.Unfortunately, this isn't proven to work at all, and it'll be a long time before it could be. In theory, a drug like that would need to be taken by healthy people, probably every day for years, with essentially no side effects. That's incredibly tough to demonstrate the safety and efficacy of, especially on a large scale.But the reason some researchers think it's possible is the way that rapamycin works on a cellular level. It affects a pathway that helps regulate growth. That pathway can be switched into a more conservative mode where it grows less and consumes less - lack of nutrients seems to trigger the same effect, which may be why fasting helps people live longer. It seems that rapamycin can do the same thing in cells, though this has not yet been demonstrated in humans.A <a href="http://www.ncbi.nlm.nih.gov/pubmed/19587680">study by the NIH</a>, for example, shows that feeding mice rapamycin can extend their lives, though again, many things that have been shown to work in mice never work in humans. Another big concern is immunosuppression. If rapamycin suppresses the immune system of an elderly person, even as it helps slow their cellular aging process, that may be too much of a negative side effect.Because of this potentially huge limitation, Novartis is actively trying to find a rapamycin derivative that is not an immunosuppressant. A recent <a href="http://stm.sciencemag.org/content/6/268/268ra179">company-funded study</a> showed that one particular derivative seemed to improve the immune response of a group of elderly people in response to a flu shot. While a flu shot is not the same as a real infection and further testing is needed, it's an exciting development for Novartis, suggesting there may be a way around some of rapamycin's potential pitfalls.Still, until there is much more evidence about rapamycin's safety and efficacy, it's worth remembering that when it comes to medicines that can actually extend the life of a healthy person, "the batting average is zero," S. Jay Olshansky, a professor of public health at the University of Illinois, tells Bloomberg Businessweek.Sadly, Sehgal himself never got to see how far the excitement about his discovery has come. As his son <a href="http://www.sehgal.net/surenshistory.htm">writes</a>, he died in 2003, five years after a diagnosis of stage 4 metastatic colon cancer.Read the full story of rapamycin at <a href="http://www.bloomberg.com/news/features/2015-02-12/does-a-real-anti-aging-pill-already-exist-">Bloomberg Businessweek</a>. <div class="margin-top"> <h3>NOW WATCH: <a href="http://www.businessinsider.com/why-men-cheat-affair-love-sex-psychotherapist-2015-1">Research Reveals Why Men Cheat, And It's Not What You Think</a></h3> <div> <div> <div class="ooyala-video-player" data-video-autoplay="false" data-video-id="9vdnlycjo8Di2vj5XaYNQCb3Cc2NYbee" data-player-variable="ooyalapopvideo" id="ooyalaplayer_popvideo" style="width:1280px;height:720px"></div> </div> </div> </div>

A rogue doctor saved a potential miracle drug by storing samples in his home after being told to throw them away

Almost 200 top business leaders signed a letter calling for Britain to stay in the EU

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Google Doodle celebrates Zohra Sehgal — Everyone's favourite dadi, an Indian royal and Doctor Who star

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A rogue doctor saved a potential miracle drug by storing samples in his home after being told to throw them away

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Almost 200 top business leaders signed a letter calling for Britain to stay in the EU

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