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The entire world is talking about <keyword id="19918897" type="General" weightage="20" keywordseo="Ozempic" source="keywords">Ozempic</keyword>, its ability to aid <keyword id="19923802" type="General" weightage="20" keywordseo="weight-loss" source="keywords">weight loss</keyword> having made it a favourite amongst individuals across all age groups. But this fairly new <keyword id="20037810" type="General" weightage="20" keywordseo="diabetes-drug" source="keywords">diabetes drug</keyword> seems to have a few more tricks up its sleeve. New research has found that Ozempic (or <keyword id="20037812" type="General" weightage="20" keywordseo="semaglutide" source="keywords">semaglutide</keyword>), already a staple in diabetes and weight-loss treatments, might offer significant relief for <keyword id="23775575" type="General" weightage="20" keywordseo="knee-osteoarthritis" source="keywords">knee osteoarthritis</keyword>! A recent phase 3 <keyword id="20663810" type="General" weightage="20" keywordseo="clinical-trial" source="keywords">clinical trial</keyword> led by an international research team showed that a weekly dose of 2.4 milligrams of semaglutide outperformed placebo treatments in relieving knee pain, supporting weight loss and improving physical activity levels for people with knee osteoarthritis. Knee osteoarthritis, a degenerative joint disease, occurs when the protective cartilage in the knee joint wears down, leading to pain, stiffness, and reduced mobility. Obesity is a major risk factor for this condition, and weight loss has been shown to alleviate symptoms. Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), works by mimicking the body's natural satiety hormone, GLP-1, thereby reducing appetite and promoting weight loss. Additionally, the drug has anti-inflammatory properties that reduce immune system overreactions, curbing swelling and tissue damage, which may explain its effectiveness in alleviating knee pain. <div type="Article" hostid="261" msid="112954964" title="Weight-loss drugs like Ozempic could help slow biological aging, researchers say" mstype="2" mssubtype="0"></div>The trial results were impressive: participants who took semaglutide lost, on average, 13.7 percent of their body weight compared to 3.2 percent for those on the placebo. Pain scores also dropped significantly more in the semaglutide group—by 41.7 points compared to 27.5 points on a scale from 0 to 96. Rheumatologist Henning Bliddal from Copenhagen University Hospital, Denmark, highlighted the striking impact, noting that some participants experienced such significant <keyword id="20386325" type="General" weightage="20" keywordseo="pain-relief" source="keywords">pain relief</keyword> that they could no longer participate in the study. While these findings offer hope, there are some important considerations. The study received partial funding from <keyword id="19918898" type="General" weightage="20" keywordseo="Novo-Nordisk" source="keywords">Novo Nordisk</keyword>, semaglutide’s manufacturer, and there was no verification of participants’ adherence to recommended diet and exercise routines. Moreover, semaglutide is expensive, and weight can return if the drug is discontinued. However, for individuals suffering from knee osteoarthritis, the prospect of a drug that can alleviate pain, promote weight loss, and improve physical function is truly exciting. As further research is conducted, we may soon see semaglutide emerge as a valuable tool in the management of this debilitating condition. <div type="Article" hostid="261" msid="111022230" title="Top doctor warns against taking weight loss drugs such as Ozempic to get &amp;#39;beach body ready&amp;#39; for summer" mstype="2" mssubtype="0"></div>

Ozempic study shows it can ease severe knee pain alongside its weight loss benefits!

Weight loss drugs' messy rise: How Ozempic, Wegovy, and Mounjaro really affect patients &mdash; and what comes next 

<ul class="summary-list"><li>Staci Rice had tried all sorts of fad diets before trying weight loss drug semaglutide.</li><li>It has been a "miracle" for Rice, who hopes to take it long-term.</li></ul>Staci Rice had tried "every diet around" before she started taking the new <a href="https://www.insider.com/weight-loss-drug-semaglutide-called-game-changer-for-obesity-2021-12">game-changing weight loss drug semaglutide</a>.Rice, 40, who lives in Gray, Georgia, would try a different diet each spring before a beach holiday. But one day she saw an advert for semaglutide while scrolling Facebook and noticed it was cheaper than previous weight loss plans she'd tried.Semaglutide, which suppresses appetite, was originally developed for diabetes and sold as Ozempic, but was approved for weight loss by the FDA in 2021 under the name Wegovy.Hype has quickly built around the drug, leading to <a href="https://www.insider.com/Semaglutide-diabetes-drug-shortages-linked-to-tiktok-weight-loss-trend-2022-6">shortages</a> and <a href="https://www.insider.com/ozempic-celebrities-denied-semaglutide-wegovy-weight-loss-drugs-khloe-kardashian-2023-3">rumors that it's used by celebrities.</a> Semaglutide isn't cheap, costing up to $1,300 a month, which is why some people have turned to <a href="https://www.insider.com/buy-compounded-semaglutide-online-risks-wegovy-ozempic-2023-1">compounded versions of the drug</a> despite the potential risks.While many people have had positive experiences on semaglutide, <a href="https://www.insider.com/woman-ozempic-eat-food-vomit-weight-loss-drugs-semaglutide-2023-3">some people say</a> the <a href="https://www.insider.com/side-effects-of-semaglutide-wegoy-ozempicweight-loss-drug-2022-11">side effects</a>, such as nausea and constipation, are severe enough they've had to quit.When Rice acquired compounded semaglutide from a nurse practitioner at a weight loss clinic she thought she would only take it short-term until after her vacation (which is when she'd usually quit a diet), but she decided to keep going.Rice lost 62 pounds in the eight months after she started taking it in May 2022. In January 2023, she moved her focus to <a href="https://www.insider.com/avoid-weight-gain-after-ozempic-with-maintenance-dose-doctor-2023-3">maintenance</a> and started injecting semaglutide every 10 days instead of weekly, she said. Her appetite has come back a little, but she has managed to maintain her weight.Rice hopes to reduce the frequency of the shots further but never wants to stop taking the medication, she said. "I'm actually looking forward to it being long-term because I know myself and my habits, and if I don't have something like that, then I will regain the weight," Rice said.After years of fad diets, which <a href="https://www.insider.com/fad-diet-red-flags-dangerous-dietitians-2022-12">health experts warn against</a>, Rice said semaglutide has been a game-changer because she hasn't cut out food groups and doesn't feel deprived. She hasn't changed her diet, but simply eats smaller portions of what she ate before. The smaller portions also means she saves money on groceries, she said.For her, the investment is worth it."Semaglutide has changed my life and I hope it's around forever," Rice said. "It's been a miracle for me."<h2>Rice's 'food noise' disappeared on semaglutide</h2><div type="image" title="Staci Rice" height="1500" width="2000" msid="99514514" hostid="261" sizebytes="64764"></div>Rice didn't immediately notice a difference in how she felt when she started semaglutide but she did get a dry mouth that didn't go away when she drank water and a bloated stomach, as well as some nausea, and fatigue, she said.Her weight fluctuated for a little while, which was frustrating, but she was eating much smaller portions by month three, she said."The food noise was gone," Rice said.While she used to wake up wanting sugar, <a href="https://www.insider.com/semaglutide-ozempic-disgusted-favorite-foods-2022-11">all her cravings and the desire to snack have disappeared</a>, she said. <h2>Rice orders kids' meals now</h2>When Rice goes out for a meal now, she either orders a kid's meal or takes her leftovers to go and will get one if not two further meals out of it, she said. Rice also prefers healthier foods now and tries to eat enough to keep her energy up.She also takes <a href="https://www.insider.com/guides/health/should-i-take-vitamins">multivitamins</a> to ensure she is getting all the nutrients she needs while eating less. Rice never used to exercise because she didn't like it and had knee pain from an injury. But she has noticed the inflammation has reduced since she lost weight, and she now enjoys exercise more, she said. For the first time in three years, Rice managed to run after her dog.As well as a smaller appetite, Rice is also among <a href="https://www.insider.com/semaglutide-alcohol-addiction-alcoholism-treatment-weight-loss-drug-2022-10">users who have found they no longer have the urge to drink</a> on semaglutide. She only used to drink alcohol occasionally but no longer craves it at all. Rice has been sharing her journey on <a href="https://www.tiktok.com/@staci402?lang=en" target="_blank" rel="noopener">TikTok</a> and is surprised by her own confidence to do so."Before, I felt like a nobody," Rice said. "But now my confidence is sky-high, I'm able to stand up and talk in front of people, and that is huge to me."

A woman who lost 62 pounds on Ozempic says the cravings and 'food noise' in her head disappeared

You Searched For "ozempic for knee pain" and got 3 results

Ozempic study shows it can ease severe knee pain alongside its weight loss benefits!

Ashmita Gupta

Weight loss drugs' messy rise: How Ozempic, Wegovy, and Mounjaro really affect patients and what comes next

Hilary Brueck,Gabby Landsverk…

A woman who lost 62 pounds on Ozempic says the cravings and 'food noise' in her head disappeared

Rachel Hosie

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