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Imagine if the reason you’re struggling with <keyword id="19923801" type="General" weightage="100" keywordseo="weight-gain" source="keywords">weight gain</keyword> wasn’t about the number of calories you eat or how much you hit the gym, but rather a hidden culprit inside your body — a misalignment between two powerful <keyword id="22853509" type="General" weightage="20" keywordseo="internal-clocks" source="keywords">internal clocks</keyword>: the one in your brain and the one in your liver. New research reveals that this mismatch could be driving unhealthy <keyword id="20000883" type="General" weightage="20" keywordseo="eating-habits" source="keywords">eating habits</keyword> and contributing to obesity, suggesting that fixing the timing of these body clocks might just be the key to tackling weight gain and metabolic issues. Your body’s <keyword id="20016193" type="General" weightage="20" keywordseo="circadian-rhythm" source="keywords">circadian rhythm</keyword>, or internal clock, is like the conductor of an orchestra, ensuring that everything — your sleep, digestion, and <keyword id="20025272" type="General" weightage="20" keywordseo="metabolism" source="keywords">metabolism</keyword> — runs on time. While your brain’s "master clock" is set by light, helping you follow a 24-hour day, your liver follows its own schedule, mostly governed by when you eat. When these two clocks get out of sync, like when you’re jetlagged or work night shifts, it can lead to chaos in your metabolism, triggering overeating and weight gain. A fascinating study in mice has uncovered that when the brain’s circadian rhythm doesn’t match up with the liver’s clock, it creates a disruption in eating patterns. Mice with a broken liver clock began to overeat, especially during their usual rest time—leading to unhealthy weight gain. However, when researchers severed the communication line between the liver and the brain (via a nerve called the hepatic vagal afferent nerve or HVAN), this overeating behavior was reduced, showing that the neural connection between the liver and brain could be a potential target to treat obesity. Why does this matter? Well, for humans, this could open a whole new avenue for tackling obesity and other metabolic diseases caused by disruptions in our body’s natural rhythms. It’s a breakthrough that points to the possibility of resetting the internal clocks to restore balance, curb overeating, and ultimately help people struggling with weight gain. This discovery isn’t just about fixing what you eat, but when you eat — unlocking a new understanding of how our body’s timing can make all the difference. So, next time you're battling the scale, it might not just be about diet or exercise — it could be time to check your body’s clocks and give them a tune-up. The findings of this research have been published in Science and can be accessed <a href="https://doi.org/10.1126/science.adn2786" data-type="tilCustomLink">here</a>.

Are your internal clocks messing with your weight? Here’s what new research says

Research has revealed how a pathway in the brain that typically provides signals to stop eating may be altered by <keyword id="15817974" type="General" weightage="20" keywordseo="early-life-trauma" source="Orion">early life trauma</keyword>. The discovery, obtained from studies in mice adds new perspective to <keyword id="14081" type="General" weightage="20" keywordseo="binge-eating" source="Orion">binge eating</keyword> and obesity. Now, a Virginia Tech scientist has identified how early <keyword id="15817971" type="General" weightage="20" keywordseo="life-trauma" source="Orion">life trauma</keyword> may change the brain to increase the risk of binge eating later in life. Research led by principal investigator Sora Shin, an assistant professor with the Fralin Biomedical Research Institute at VTC, revealed how a pathway in the brain that typically provides signals to stop eating may be altered by early life trauma. The discovery, obtained from studies in mice, in Nature Neuroscience on Dec. 12 adds new perspective to behaviors such as binge eating and obesity. "We wanted to know the mechanism underlying how early life trauma induces these eating disorders," said Shin, who is also an assistant professor in the Department of Human Nutrition, Foods and Exercise in the College of Agriculture and Life Sciences. "What we found is a specific brain circuit that is vulnerable to stress, causing it to become dysfunctional." "This finding speaks to a set of broader health questions, which is how life's health course is set based on certain early experiences," said Michael Friedlander, executive director of the Fralin Biomedical Research Institute at VTC and Virginia Tech's vice president for Health Sciences and Technology. "We are increasingly aware that early experiences and exposures ranging from those that occur even pre-conception in future parents through those that the fetus experiences in utero and to those that the child experiences throughout postnatal life can have dramatic impact on our health course throughout life. Dr. Shin's latest discovery in this one particular case shines an important new mechanistic light on this process. Like all innovative research, the study also raises additional important questions such as whether and how these effects can be changed. Dr. Shin's research can empower such lines of inquiry since a neural substrate and mechanism have been identified." Stress symptoms can affect our body, thoughts and feelings, and behavior. In Shin's finding, the stress on mice who were separated from their litter mates may trigger life-long eating behavior changes. Binge-eating disorder is marked by recurring episodes of eating more rapidly than normal to beyond a feeling of fullness, and feelings of distress and loss of control, according to the Diagnostic and Statistical Manual of Mental Disorders. To identify the connection between the disorder and early life trauma, Shin and her lab team studied the impact of a hormone in the brain called leptin. Leptin has long been known suppress appetite and weight gain by signaling the brain that it's time to stop eating. The team found that in mice that experienced early life stress and exhibited behavior similar to binge-eating, leptin is less effective in a part of the brain called the lateral hypothalamus, where many behaviors are regulated. Without these signals from the brain, the overeating continues. Digging deeper, the researchers identified neurons in another part of the brain called the ventrolateral periaqueductal gray that respond to the message from leptin and lateral hypothalamus, thereby regulating binge eating. "There is much more research to do," Shin said, "but by knowing the specific molecule and receptors in the brain to target, we can now provide insight and the foundation for developing therapeutic strategies for the disorder." The discovery's potential is significant. "This paper extends and brings considerable hope that the progress in the neuroscience of binge-eating disorder. Advanced imaging, and brain circuitry may allow experts to find risk factors, triggers, and causes," said Mark S. Gold, professor in the department of psychiatry at Washington University in St. Louis and formerly a University of Florida Distinguished Professor, Eminent Scholar, and chairman of the department of psychiatry, who was not involved in the research. "Studying the role of traumatic and early life experiences of this pathway may help us fine-tune prevention and early intervention efforts to prevent binge-eating disorder." SEE ALSO: <a href="https://www.businessinsider.in/thelife/personalities/news/i-am-glad-i-fd-up-so-much-in-life-that-it-is-content-now-says-ankur-warikoo/articleshow/96282722.cms">I am glad I F**%*D up so much in life that it is content now says Ankur Warikoo</a> <a href="https://www.businessinsider.in/careers/news/tech-layoffs-surpass-great-recession-levels-set-to-get-worse-in-early-2023/articleshow/96314678.cms">Tech layoffs surpass Great Recession levels, set to get worse in early 2023</a>

Binge eating is linked to early life trauma

<ul class="summary-list"><li>Having a body mass index (BMI) that is too high or too low can impact your ability to conceive.</li><li>If you are over<keyword id="17819" type="ORGANIZATION" weightage="60" keywordseo="weight">weight</keyword> or obese, losing weight can boost <keyword id="6414006" type="UNKNOWN" weightage="60" keywordseo="fertility">fertility</keyword> and increase the chances of getting pregnant.</li><li>Weight is closely linked to underlying fertility issues in both men and women.</li></ul>If you are trying to conceive, maintaining a healthy weight can help <a href="https://www.womenshealth.gov/healthy-weight/weight-fertility-and-pregnancy" target="_blank" rel="noopener">increase your chances</a> of getting pregnant. Having a <a href="https://www.insider.com/is-bmi-accurate" target="_blank" rel="noopener">body mass index (BMI)</a> that is too high (&gt;25) or too low (&lt;18) can impact your ability to conceive and <a href="https://www.womenshealth.gov/healthy-weight/weight-fertility-and-pregnancy" target="_blank" rel="noopener">increase complications</a> during <keyword id="6357793" type="UNKNOWN" weightage="60" keywordseo="pregnancy">pregnancy</keyword>, says<a href="https://rmanetwork.com/specialists/emily-k-osman/" target="_blank" rel="noopener"> Emily Osman</a>, MD, an OB-GYN and reproductive endocrinologist with the RMA network in New Jersey. "Weight is closely linked to underlying fertility issues in both men and women," Osman says, adding that an unhealthy weight can also "reduce the chances of fertility treatments being successful."Find out more about how weight affects fertility, and what you can do about it.<h2>How weight affects fertility</h2>About<a href="https://www.asrm.org/topics/topics-index/weight/" target="_blank" rel="noopener"> 12%</a> of female infertility may be connected to the patient's weight being too high or too low, according to the American Society of Reproductive Medicine (ASRM). "For women, being underweight or overweight may be associated with what's known as ovulatory dysfunction, or the ability to regularly release an egg in order to conceive," Osman says. General advice: Ideally, people trying to conceive should be within the <a href="https://www.cdc.gov/healthyweight/assessing/bmi/adult_bmi/index.html" target="_blank" rel="noopener">healthy body-mass index (BMI) range</a> of 18.5 to 24.9, Osman says. However, that's not possible for everyone. For those who are among the <a href="https://www.cdc.gov/nchs/data/hestat/obesity-adult-17-18/obesity-adult.htm" target="_blank" rel="noopener">74% of overweight or obese Americans</a>, a moderate weight loss of 7% and an increase in activity can improve fertility, says Osman's colleague,<a href="https://rmanetwork.com/specialists/jason-m-franasiak/" target="_blank" rel="noopener"> Jason Franasiak,</a> MD, an infertility specialist. That's because body fat affects hormones, including those needed to mature and release an egg. Underweight women may stop releasing <a href="https://www.cancer.gov/publications/dictionaries/cancer-terms/def/gonadotropin-releasing-hormone" target="_blank" rel="noopener">gonadotropin-releasing hormone</a> (GnRH), which leads to a condition known as<a href="https://www.nichd.nih.gov/health/topics/amenorrhea/conditioninfo/causes" target="_blank" rel="noopener"> hypothalamic amenorrhea</a>, where there is no menstrual cycle, no egg release, and therefore no egg to fertilize. Overweight individuals are more likely to have<a href="https://pubmed.ncbi.nlm.nih.gov/18641044/#:~:text=Results:%20Women%20with%20very%20low,l%20increase%20in%20estradiol%20levels." target="_blank" rel="noopener"> higher estrogen levels</a>. In females, high estrogen levels can<a href="https://www.asrm.org/topics/topics-index/weight/" target="_blank" rel="noopener"> shut down</a> the menstrual cycle, again leaving no egg to be fertilized. In males, higher estrogen levels can<a href="https://www.pennmedicine.org/updates/blogs/fertility-blog/2014/may/whats-the-link-between-obesity-and-infertility#:~:text=Being%20overweight%20or%20obese%20can,for%20Reproductive%20Medicine%20(ASRM)." target="_blank" rel="noopener"> impact testicular function</a>, leading to<a href="https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1108774" target="_blank" rel="noopener"> lower sperm count</a> and, thus, decreased chances for a sperm to fertilize an egg.Overweight females are also at a<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845358/" target="_blank" rel="noopener"> higher risk</a> for physical conditions including <a href="https://www.insider.com/what-is-pcos" target="_blank" rel="noopener">polycystic ovary syndrome</a> (PCOS), tubal infections, and <a href="https://www.insider.com/do-i-have-endometriosis" target="_blank" rel="noopener">endometriosis</a>, all of which can make it more difficult to conceive and carry a pregnancy to term. <h2>How weight affects pregnancy <keyword id="6354750" type="UNKNOWN" weightage="100" keywordseo="health">health</keyword></h2> In addition to impacting fertility, weight can also affect the outcome of pregnancy. "Maternal obesity is strongly associated with mom and baby complications," says Franasiak. Being underweight or overweight brings its own set of risks:<ul><li>Being underweight is<a href="https://www.ok.gov/health2/documents/Prepregnancy%20Underweight%20and%20Related%20Prematurity%20in%20Newborn_Jan2020.pdf" target="_blank" rel="noopener"> linked</a> to complications such as preterm labor and low birth weight.</li><li>Being overweight increases the risk of<a href="https://www.nature.com/articles/pr9201134" target="_blank" rel="noopener"> almost all pregnancy complications, </a>including miscarriage, high blood pressure and pre-eclampsia.</li></ul><h3>Obesity-related complications in pregnancy </h3><ul><li>Miscarriage and stillbirth: Obese (BMI &gt;30) pregnant people have a roughly<a href="https://academic.oup.com/humrep/article/19/7/1644/2356447" target="_blank" rel="noopener"> 20% increased risk for first-trimester miscarriages and are three times more likely</a> to experience recurring <a href="https://www.insider.com/how-long-does-miscarriage-last" target="_blank" rel="noopener">miscarriages</a> than those with a healthy BMI. The risk for stillbirth also<a href="https://www.acog.org/womens-health/faqs/obesity-and-pregnancy" target="_blank" rel="noopener"> increases with higher BMI</a>. </li><li>Gestational diabetes: Overweight (BMI 25-29.9) and obese (BMI &gt;30) pregnant people have an increased risk for gestational diabetes. Their collective risk accounts for<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866592/" target="_blank" rel="noopener"> roughly half</a> of gestational diabetes cases. In turn, gestational diabetes<a href="https://www.marchofdimes.org/complications/gestational-diabetes.aspx" target="_blank" rel="noopener"> increases risks</a> for other pregnancy complications including high blood pressure, birth injuries to the baby and mother, and stillbirth. </li><li>Birth defects: Overweight pregnant mothers are <a href="https://www.acog.org/womens-health/faqs/obesity-and-pregnancy" target="_blank" rel="noopener">more likely</a> to have children with heart or neural tube defects, such as <a href="https://www.ninds.nih.gov/disorders/patient-caregiver-education/fact-sheets/spina-bifida-fact-sheet" target="_blank" rel="noopener">spina bifida</a>, and are more likely to give birth prematurely, which comes with a host of<a href="https://www.marchofdimes.org/complications/premature-babies.aspx" target="_blank" rel="noopener"> lifelong health risks</a> for the baby. </li></ul><h2>How does losing weight increase fertility?</h2>It's a good idea to try to get your body weight closer to a healthy range before trying to conceive, Franasiak says. However, if your BMI is much higher than 24.9, even small changes can<a href="https://www.acog.org/womens-health/faqs/obesity-and-pregnancy" target="_blank" rel="noopener"> boost your fertility and lead to a healthier pregnancy</a>. "Current<a href="https://www.acog.org/womens-health/faqs/obesity-and-pregnancy" target="_blank" rel="noopener"> recommendations</a> include a weight loss of 7% of body weight and increased weekly physical activity of at least 150 minutes - or 30 minutes in 5 out of 7 days - which can be as simple as walking," Fransiak says.Eating healthy and moving regularly can help you<a href="https://www.cdc.gov/healthyweight/losing_weight/index.html" target="_blank" rel="noopener"> achieve</a> moderate weight loss, Fransiak says. <a href="https://www.acog.org/womens-health/faqs/obesity-and-pregnancy" target="_blank" rel="noopener"> Ask your doctor</a> for a referral to a nutritionist who can help support weight loss or gain; doing so may increase your chances of conception and healthy pregnancy. If your doctor diagnoses<a href="https://www.insider.com/what-is-diabetes" target="_blank" rel="noopener"> insulin resistance</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475283/" target="_blank" rel="noopener">PCOS</a>, they might prescribe a medication like<a href="https://medlineplus.gov/druginfo/meds/a696005.html" target="_blank" rel="noopener"> metformin</a>, but there are no weight-loss drugs that are commonly used for people trying to conceive since weight loss medications are<a href="https://www.acog.org/womens-health/faqs/obesity-and-pregnancy" target="_blank" rel="noopener"> not recommended</a> for those trying to have a baby.People who are very overweight and have struggled to lose weight may also consider surgical weight-loss options, but should not try to get pregnant for<a href="https://www.acog.org/womens-health/faqs/obesity-and-pregnancy" target="_blank" rel="noopener"> at least a year</a> after surgery, Fransiak says. <h2>Insider's takeaway</h2>Weight can impact conception for both males and females, and it can affect pregnancy health for mother and child. It<a href="https://www.acog.org/womens-health/faqs/obesity-and-pregnancy" target="_blank" rel="noopener"> is possible</a> to conceive and have a healthy pregnancy if you are overweight or obese. However having a BMI of less than 18.5 or more than 24.9 can affect your hormonal health, affecting fertility and making it difficult to conceive. For overweight individuals, a small weight loss of<a href="https://www.acog.org/womens-health/faqs/obesity-and-pregnancy" target="_blank" rel="noopener"> 5-7%</a> of body weight can boost your fertility, increase your chances of getting pregnant, and decrease health risks during pregnancy. Your doctor can work with you to put together a plan for healthy weight loss. "Weight loss can be challenging, but it will help to increase the likelihood of conception and a healthy pregnancy," Osman says. <h2>Related stories from <a href="https://www.insider.com/health-reference" target="_blank" rel="noopener">Health Reference</a>:</h2><ul><li><a href="https://www.insider.com/what-helps-with-pregnancy-nausea">How to reduce your pregnancy nausea</a></li><li><a href="https://www.insider.com/does-pregnancy-cause-acne">Yes, pregnancy can cause acne. Here's when you will breakout the worst and how to treat it.</a></li><li><a href="https://www.insider.com/when-do-pregnancy-cravings-start">When pregnancy cravings start and how long they last</a></li><li><a href="https://www.insider.com/is-tylenol-safe-for-pregnancy">Yes, Tylenol is safe for pregnancy. Here's the right dosage</a></li><li><a href="https://www.insider.com/can-you-get-a-flu-shot-while-pregnant">Yes, you can get a flu shot while pregnant. Here's the best time to get it.</a></li><li><a href="https://www.insider.com/ob-gyn-doctors-biggest-pregnancy-myths-debunked-2019-10">Doctors debunk the 25 biggest pregnancy myths</a></li></ul>

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Are your internal clocks messing with your weight? Here’s what new research says

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Binge eating is linked to early life trauma

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How weight impacts your chances of getting pregnant

Kelly Burch,Veronique Tache

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