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<ul class="summary-list"><li>Looking after our musculoskeletal health can help us stay strong and active as we age.</li><li>Dr. Vonda Wright describes ages 35 to 45 as "the critical decade" for developing healthy habits.</li></ul>A doctor who specializes in active aging shared three things she does to stay healthy and mobile as she grows older.Dr. Vonda Wright, a double board-certified orthopedic surgeon based in Florida, whose roles include helping Olympians avoid injury, told Business Insider that maintaining powerful muscles and strong bones is key to leading a long, healthy life.Research suggests that 50% of people who break a hip never fully regain their mobility, and 30% over 65 die within a year, Wright said.That's why Wright sees healthy musculoskeletal aging as "a lifelong pursuit." Developing <a target="_blank" href="https://www.businessinsider.com/longevity-lifestyle-changes-live-longer-healthy-habits-genes-study-2024-5">healthy habits</a> between the ages of 35 and 45, what she calls "the critical decade," can help you maintain your mobility and strength as you age, she said."It's critical that we start paying attention now," Wright, the author of "Fitness After 40," added.Wright shared three tips that she sticks to herself for staying active well into her golden years.<h2 id="577bd9cc-7616-464c-803a-bc8a1f43499f">Learn how to lift weights</h2>Wright recommends <a target="_blank" href="https://www.businessinsider.com/guides/health/fitness/how-to-build-muscle">strength training to build as much muscle</a> as possible, particularly in the critical decade.As we age, we naturally lose muscle mass, which is crucial for everyday movements like standing up from a chair. The process starts in our 30s and 40s and picks up between the ages of 65 and 80."Let's build as much muscle as we can because from that, we will then live longer and be stronger and build better bones," she said. "If we need to, let's hire somebody. Let's save up a little money and learn how to lift."A growing body of research has linked <a target="_blank" href="https://www.businessinsider.com/weight-lifting-and-cardio-may-help-you-live-longer-study-2022-9">lifting weights to living longer</a>. In a 2022 study published in the journal JAMA, researchers looked at data from the National Health Interview Survey that detailed how much and what type of exercise more than 115,000 people over the age of 65 did for around eight years. They found that those who did strength training at least twice a week were less likely to die of any cause than those who did less.<h2 id="0c46e49f-3572-4d56-be5c-c5427b17befa">Eat a high-protein diet and plenty of vitamin D</h2><div type="image" title="A poke bowl." height="4000" width="6000" msid="115173931" hostid="261" sizebytes="634046"></div>In order to <a target="_blank" href="https://www.businessinsider.com/muscle-building-potential-gains-progress-monthly-trainer-2022-4">build muscle</a>, you also have to make sure you eat enough protein, Wright said.<a target="_blank" href="https://www.businessinsider.com/easy-calculate-how-much-protein-coach-olympians-2024-9">Mike Molloy</a>, a nutrition coach to elite athletes, previously told BI that he advises people to eat about 0.75 grams of protein per pound of total body mass, or 1.6 grams per kilogram.Protein is a major component of bone, so it's important for building strong bones, too, Wright said.Vitamin D, which helps regulate the amount of calcium and phosphate in the body, is crucial for maintaining bone density, she said, so getting enough is vital. Most people get enough vitamin D from sunlight, but those living in colder climates are unlikely to get enough during winter and fall.<a target="_blank" href="https://www.businessinsider.com/what-you-have-to-eat-to-get-enough-vitamin-d-2019-2">Vitamin D is found</a> in a small number of foods, such as oily fish, red meat, and egg yolks.<h2 id="945b42b7-9818-42d7-bd3d-a395ef4b83a3">Take exercise micro-breaks from your desk</h2>Most of us spend our entire careers sitting at a desk 10 hours a day, which leads to muscle loss and an "incredibly weak" musculoskeletal system, Wright said. "It's one of the hallmarks of aging," she said.It's also linked to early death. A 2024 <a target="_blank" href="https://www.ahajournals.org/doi/10.1161/JAHA.123.031156">study</a> published in the Journal of the American Heart Association using data from almost 6,000 mobile women aged 63 to 99 found that those who sat for 11.6 hours or more a day were 57% more likely to die from any cause.To combat this, Wright recommends <a target="_blank" href="https://www.businessinsider.com/short-workout-improve-fitness-exercise-snacks-2019-1">taking short breaks</a> regularly throughout the day to do some physical activity."Doing ten wall squats or ten chair squats or ten prisoner squats is really amazing for maintaining musculoskeletal health," she said.She recommended setting a reminder to go off every 45 minutes.

A sports medicine doctor shares 3 things she does to maintain muscle and stay active as she grows older

A <keyword id="20558223" type="General" weightage="20" keywordseo="blood-test" source="keywords">blood test</keyword> measuring two specific fats, along with <keyword id="20100635" type="General" weightage="20" keywordseo="inflammation" source="keywords">inflammation</keyword>, could help predict a woman's risk of developing heart conditions in the next 30 years, according to a study of nearly 28,000 women in the US. The two fats in one's blood sample that the test measured were LDL, or 'bad' <keyword id="19898368" type="General" weightage="20" keywordseo="cholesterol" source="keywords">cholesterol</keyword>, and lipoprotein(a), which is partly made of LDL. Inflammation was measured by detecting levels of high-sensitivity C-reactive proteins. When the three measures -- inflammation, cholesterol and lipoprotein(a) -- of a woman's blood sample were analysed together, researchers found that women having the highest levels were 2.6 times more likely to have a major adverse <keyword id="23010849" type="General" weightage="20" keywordseo="cardiovascular-event" source="keywords">cardiovascular event</keyword>, including a heart attack. The link was found to be even stronger for stroke -- women with the most elevated levels were 3.7 times more likely to experience a stroke over the next 30 years, the team of researchers, including those from Brigham and Women's Hospital, US, said. They added that the three measures can better predict the risk of major cardiovascular events over the next three decades than measuring only one. The findings were published in the <keyword id="20060225" type="General" weightage="20" keywordseo="New-England-Journal-of-Medicine" source="keywords">New England Journal of Medicine</keyword>. "We can't treat what we don't measure, and we hope these findings move the field closer to identifying even earlier ways to detect and prevent heart disease," author Paul M Ridker, Brigham and Women's Hospital, said. For the study, the researchers analysed blood samples and medical information from 27,939 healthcare providers living in the US, who participated in the <keyword id="23010850" type="General" weightage="20" keywordseo="Womens-Health-Study" source="keywords" meta.keywordsubtype="org" meta.entityname="Women's Health Study" meta.hostid="261" meta.entityid="Women's Health Study">Women's Health Study</keyword>. The women were on average aged 55 at the study's start (1992-1995) and followed for 30 years. Over the study period, about 3,660 of the women experienced a major cardiovascular event for the first time, including a heart attack, stroke, or death due to related reasons. Assessing cardiovascular risk individually due to each of the three measures, the researchers found that the women having the highest levels of inflammation had a 70 % higher chance of a major cardiovascular event. The women with the highest levels of 'bad' cholesterol and lipoprotein(a) were found to be at a 36 % and 33 % higher chance, respectively, of developing heart-related conditions. While only women were studied for this research, the researchers expect to find similar results in men, they said. Studies in recent years have shown how high levels of inflammation can interact with fats to compound heart disease risks, which helps explain why lower levels are better, according to the researchers. They explained that immune cells, which help the body repair wounds or infection, can also sense the accumulation of extra cholesterol in cells or become active in response to the build-up of plaque and send out inflammatory signals. This creates a hyper-inflammatory environment where plaque can form, become larger, or even rupture -- and cause cardiovascular events, the authors said. Through a combination of lifestyle changes and drug therapy, the researchers said that each of the three risk factors can be addressed. Studies have shown that lowering cholesterol and inflammation both significantly reduce the risk of heart attack and stroke, they said. The new data strongly supports earlier and more aggressive use of targeted preventive interventions, particularly among women for whom cardiovascular disease remains under-diagnosed and under-treated, the researchers said.

Fats in blood, with inflammation, could better predict heart disease risk in women, study finds

Going vegan for eight weeks was found to be linked to lowering <keyword id="20730859" type="General" weightage="20" keywordseo="biological-age" source="keywords">biological age</keyword>, according to a study published in the journal BioMed Central (BMC) Medicine. Researchers looked at the molecular effects of the <keyword id="20041126" type="General" weightage="20" keywordseo="plant-based-diet" source="keywords">plant-based diet</keyword> that abstains from consuming animal food products, such as dairy. The diet largely includes eating fruits and vegetables, along with grains, beans and nuts. The researchers, including those at <keyword id="20089812" type="General" weightage="20" keywordseo="Stanford-University" source="keywords" meta.keywordsubtype="org" meta.entityname="Stanford University" meta.hostid="83" meta.entityid="Stanford University">Stanford University</keyword>, US, found that consuming the plant-based diet was related with changes in how a gene expressed itself, or gene behaviour, without changing the DNA itself. Specifically, they looked at <keyword id="21419638" type="General" weightage="20" keywordseo="DNA-methylation" source="keywords">DNA methylation</keyword>, known to be able to "turn off" or "silence" a gene, thereby not allowing it to express itself. Higher levels of DNA methylation is associated with a higher biological age. It is one of the epigenetic processes, which affect the behaviour of a gene by altering its environment. For eight weeks, the team followed 21 pairs of adult identical twins -- one half of each pair consumed an omnivorous diet, including meat, eggs and dairy, while the other consumed a vegan one. Identical twins share a significant amount of their genetic makeup. On average, the participants were aged 40 years and had a body mass index (BMI) in the overweight category. About 77% of the group were women. After eight weeks, the researchers observed a 'younger' heart, liver, inflammatory and metabolic system among the participants consuming the <keyword id="20703587" type="General" weightage="100" keywordseo="vegan-diet" source="keywords">vegan diet</keyword>. These changes were not seen in those eating the omnivorous diet. However, the authors cautioned that the extent to which these changes could be attributed to their diets was unclear. They noted that on average, the individuals on the vegan diet lost two kilograms more compared to those on the omnivorous diet. The results suggest that the weight loss could have contributed to lowering of the biological age in the vegan group, the researchers said. Reacting to the study, Tom Sanders, a professor emeritus of Nutrition and Dietetics at King's College London, and not involved in the study, said that the findings might be favourable for vegans in terms of ageing. However, the diet can come with <keyword id="21204758" type="General" weightage="20" keywordseo="micronutrient-deficiencies" source="keywords">micronutrient deficiencies</keyword>, which often take years to exert harmful effects, Sanders said. "For example, unless a vegan diet is supplemented with vitamin B12 they develop vitamin B12 deficiency that causes chronic and often insidious damage to the nervous system," Sanders said. Long-term studies of vegans also find adverse effects on bone density, probably caused by very low calcium and barely adequate protein intakes, Sanders said.

Eight-week vegan diet linked to lower biological age, study finds

<ul class="summary-list"><li>North Korea is seeking medicine for Kim Jong Un's obesity, a South Korean spy agency said.</li><li>Kim, 40, is said to weigh 308 pounds and have high blood pressure and diabetes.</li></ul>North Korean officials are looking to find new drugs to treat <a target="_blank" class="" href="https://www.businessinsider.com/north-korea-fashion-kim-jong-un-lapel-pin-2024-7">Kim Jong Un</a>'s obesity-related health issues, South Korea's spy agency said.The National Intelligence Service (NIS) told lawmakers on Monday that Kim — who stands at around 5 foot 7 inches and is estimated to weigh 308 pounds — is at high risk for heart disease, one of the lawmakers, Lee Seong Kweun, told <a target="_blank" class="" href="https://apnews.com/article/north-korea-kim-jong-un-health-obesity-c4e373eeede0c494f0b96f26518eff2c">AP News</a>.Lee said lawmakers were informed that the 40-year-old leader had shown symptoms of high blood pressure and diabetes for the best part of a decade.Multiple outlets reported that Kim lost a substantial amount of weight in 2021, but he has since appeared to regain it.Now, officials are searching overseas for medicine that could treat Kim's high blood pressure and diabetes, according to the NIS, cited by Lee and Park Sunwon, another lawmaker.These lawmakers said the agency believes Kim's poor health is tied to stress as well as his smoking and drinking habits, the outlet wrote.There's also a family history of health issues. Kim's father and grandfather, who ruled the country before he came to power in 2011, died of respective heart problems.Business Insider could not independently verify AP's report. The NIS has historically been inconsistent in confirming developments in secretive North Korea, the AP said.There has been widespread speculation over Kim's health in recent years, with some citing the leader's apparent smoking and drinking habits as a risk to the country's future.Sue Mi Terry, a North Korea expert at the Center for Strategic and International Studies, <a target="_blank" class="" href="https://www.businessinsider.com/kim-jong-un-weight-gain-loss-2021-6">previously told BI</a> that health is "one of the most important indicators" of regime stability, adding that the North Korean leader's health "is the biggest wild card.""Succession is very unclear if something were to happen to Kim Jong Un," she said."We know he's unhealthy. So we need to care" about his health, she added.The NIS believes that Kim's young daughter, <a target="_blank" class="" href="https://www.businessinsider.com/kim-jong-uns-10-year-old-daughter-is-being-groomed-for-leadership">Ju Ae</a>, is likely to be Kim's heir apparent. Kim is <a target="_blank" class="" href="https://www.businessinsider.com/kim-jong-un-life-2017-8">believed to have two other children</a> and the role hasn't been officially designated.AP News reports that Ju Ae is around 10 or 11 years old. She began accompanying her father to events in 2022 and has been dubbed Kim's "most beloved" and "respected" child by state media, the outlet said.

North Korea is looking for medicine overseas to treat Kim Jong Un's obesity, spy agency says

<ul class="summary-list"><li>Dr. Florence Comite is a precision medicine doctor who specializes in healthy aging.</li><li>She shared five diet tips she shares with patients to help them live longer. </li></ul>A <a target="_blank" href="https://www.businessinsider.com/longevity-supplements-live-longer-precision-medicine-doctor-2024-3">precision medicine doctor</a> shared with Business Insider six diet tips she gives her patients to help them live healthily for as long as possible.<a target="_blank" href="https://www.businessinsider.com/essential-healthy-habits-for-your-twenties-thirties-longevity-advice-2023-12">Living longer</a> is a hot topic, and the longevity therapeutics industry is predicted to be worth $44.2 billion by 2030, according to Allied Market Research. But experts agree that nailing the basics can make a huge difference to our long-term health.One recent study found that a healthy lifestyle, including a good diet, could <a target="_blank" href="https://www.businessinsider.com/longevity-lifestyle-changes-live-longer-healthy-habits-genes-study-2024-5">add years to a person's life</a> even if they were genetically predisposed to life-shortening illnesses.A separate study from 2023 found that people who ate diets rich in whole grains, nuts, and fruit <a target="_blank" href="https://www.businessinsider.com/foods-live-10-years-longer-longevity-diet-study-2023-11">lived around 10 years longer</a> than those who consumed more red meat, processed foods, and sugary drinks.Here is how Dr. Florence Comite, an endocrinologist and founder of the New York-based <a target="_blank" href="https://comitemd.com/">Comite Center for Precision Medicine &amp; Health</a>, advises her patients to eat to help them extend their healthspans.<h2 id="35712429-2b77-46a9-9766-bb974367ad90">Cut down on ultra-processed foods</h2>"I don't think any food group is bad, but highly <a target="_blank" href="https://www.businessinsider.com/minimally-processed-grocery-store-snacks-nutritionist-2024-3">processed food</a> and overly sugar drinks can undermine your health," Comite said.What are known as ultra-processed foods are made using methods and ingredients that aren't found in a home kitchen, and are linked to an increased risk of health conditions, including <a target="_blank" href="https://www.businessinsider.com/what-is-processed-food-2019-5">cancer and obesity, as well as early death</a>.Dietitians say we should <a target="_blank" href="https://www.businessinsider.com/processed-ultra-processed-foods-ok-to-eat-2023-8">eat fewer UPFs </a>but don't need to cut them out completely, as some processed foods can be a cheap and accessible source of nutrients.<h2 id="065bc0d0-74bf-4015-902a-8987d4ebea73">Eat a Mediterranean-style diet</h2>"Don't get fixated or hung up on any particular diets out there," Comite said. "The Mediterranean way of eating is probably the healthiest."<div type="image" title="Someone spooning dressing over roasted broccoli." height="1126" width="1686" msid="110087591" hostid="261" sizebytes="141872"></div>Despite its name, the <a target="_blank" href="https://www.businessinsider.com/mediterrean-diet-healthiest-best-overall-2024-1">Mediterranean diet</a> is more of an eating plan that is low in processed foods and red meat. It mostly focuses on fruits and vegetables, legumes, olive oil, and lean protein sources, including fatty fish and chicken. Plus, you can enjoy the occasional glass of red wine, depending on which version you follow.<h2 id="b88b3fb6-8e23-49dc-b125-6b035d2d994e">Start every meal with a source of protein</h2>"One of the markers of aging that we can stop and reverse is the <a target="_blank" href="https://www.businessinsider.com/physical-signs-need-eat-more-protein-weak-hair-nails-hunger-2022-7">loss of muscle</a> that begins in our 30s," Comite said. "One of the ways to do this is to eat enough protein."The Food and Nutrition <a target="_blank" href="https://ods.od.nih.gov/HealthInformation/nutrientrecommendations.aspx">Board</a> of the National Academies of Sciences Engineering and Medicine recommends eating 0.36g of protein per pound of body weight each day, but recent studies have suggested that people looking to <a target="_blank" href="https://www.businessinsider.com/guides/health/diet-nutrition/how-much-protein-do-you-need">increase muscle mass</a> or lose weight should aim for 0.7g. For a 160-pound adult, that's 112g of protein a day, or the equivalent of around five skinless, boneless chicken breasts."I tell every patient to start every meal and every snack with a <a target="_blank" href="https://www.businessinsider.com/easy-protein-smoothie-recipe-ingredients-longevity-doctor-2024-2">source of protein</a>. So, if you're having an apple, try to have a handful of nuts or a little bit of yogurt as a source of protein with it. Or for breakfast, have something like eggs or cottage cheese," Comite said. This helps spread out the protein so you feel satiated all day, she said.<h2 id="9f55bfd6-36c6-484c-8949-e8fb99f4bad8">Eat balanced meals</h2>Comite said that eating balanced meals that contain a source of protein, fiber, and healthy fats, helps the body release <a target="_blank" href="https://www.businessinsider.com/eat-carbs-with-protein-fat-reduce-blood-sugar-spikes-crashes-2022-7">glucose more slowly</a> — avoiding the crashes that tend to follow sugary meals."Starting with protein and eating enough healthy fibers and fat allows you to feel satiated," Comite said, "and it triggers the right release of the glucose and the insulin that follows so you don't feel weak and jittery soon after eating."Dietitians have previously told BI that simply adding cheese to bread is one way to <a target="_blank" href="https://www.businessinsider.com/eat-carbs-with-protein-fat-reduce-blood-sugar-spikes-crashes-2022-7">make a meal more balanced.</a><h2 id="3240587b-1a67-486c-8360-2324fa6642c4">Don't blindly follow what others are doing</h2>Don't get caught up in how your friends are eating, or any <a target="_blank" href="https://www.businessinsider.com/fad-diet-red-flags-dangerous-dietitians-2022-12">fad diets</a>, because everyone has different needs and preferences, Comite said."For some of us, that means eating small amounts every few hours. For others, it means three square meals a day. For others, it means <a target="_blank" href="https://www.businessinsider.com/reverse-biological-age-years-fasting-study-2024-2">fasting</a> for eight or 12 hours overnight, only eating between noon and eight," she said.Just do what works for you and don't push yourself to try any fasting routines that your body can't tolerate, she said.

A precision medicine doctor shares 5 diet tips that could help you live longer

<ul class="summary-list"><li>GLP-1 medications are breakthroughs for weight loss, diabetes, and more.</li><li>Pharma companies are clamoring to produce pills or longer-lasting drugs with faster effects.</li></ul>In the race to find Ozempic 2.0, a few stand-outs are emerging.While <a target="_blank" class="" href="https://www.businessinsider.com/weight-loss-glp-1-drugs-ozempic-wegovy-mounjaro-effects-future-2023-12">GLP-1 drugs</a> have paved the way for a new era of healthcare, they have some drawbacks. They need to be injected (a draw-back for some patients), that injection must be administered once a week for effects to last, and manufacturers struggled to keep up with demand.Competition is on the way: Dozens of experimental new weight-loss medications are in development as biotech companies race to get a slice of a <a target="_blank" class="" href="https://www.businessinsider.com/economic-outlook-ozempic-economy-obesity-gdp-productivity-healthcare-novo-nordisk-2024-3">market forecast to be worth $100 billion</a>.Some are combining multiple hormones at once for enhanced effects to regulate appetite, blood sugar, and digestion. Some are trying to package these sought-after ingredients into pill form, or injectables that last longer.The next breakthrough drug may not be available until at least 2027, but the leading candidates in production give a good sense of what this market could look like in years to come."Anti-obesity medications are emerging at an astonishing pace," Dr. Christopher McGowan, a gastroenterologist and obesity medicine specialist, told Business Insider. "Forthcoming medications take the blockbuster GLP-1 medications and up the ante."<h2 id="03229fa8-bff6-4bcd-964c-60199e80d187">A new triple-action injection from Eli Lilly</h2>Why it's interesting: <a target="_blank" href="https://www.businessinsider.com/new-weight-loss-and-diabetes-drug-retatrutide-awaits-further-testing-2022-12">Retatrutide</a> is a next-gen medication that acts on three different hormones, earning it the nickname <a target="_blank" href="https://www.businessinsider.com/retatrutide-patients-lose-more-weight-than-ozempic-wegovy-mounjaro-2023-6">Triple-G.</a>That means it could lead to more weight loss than current medications like Ozempic, Wegovy, and Mounjaro, comparable to bariatric surgery.How it works: Eli Lilly's retatrutide drug is administered the same way as the market leaders Ozempic, Wegovy, Mounjaro, and Zepbound: it's a once-weekly injection.What's unique is the substance.Like semaglutide (the active ingredient in Ozempic and Wegovy), it works on GLP-1, a hormone that regulates blood sugar and appetite.Like tirzepatide (the drug in Mounjaro and Zepbound), it also works on GIP, a hormone that manages blood sugar.Uniquely, retatrutide has an additional effect, mimicking another hormone called glucagon, which may help increase the body's energy use. The idea is that it promotes weight loss by not only curbing appetite, but also burning more calories.Current research: The <a target="_blank" class="" href="https://www.nejm.org/doi/full/10.1056/NEJMoa2301972">results of mid-stage trials</a> found that patients taking retatrutide lost an average of 58 pounds in 11 months, more and faster weight loss than has been seen with drugs currently on the market.Timeline: Retatrutide is currently being studied in <a target="_blank" class="" href="https://trials.lilly.com/en-US/trial/405675">Phase III trials</a> which are scheduled to be completed in early 2026.<h2 id="e636601d-d064-4676-851b-b8a28f3debbe">A faster-acting weight-loss drug that could be a pill or injection</h2>Why it's interesting: Early research suggests <a target="_blank" href="https://www.businessinsider.com/viking-therapeutics-weight-loss-drug-ozempic-glp-1-agonists-2024-2">VK2735</a>, from California-based Viking Therapeutics, could work faster than competitors like semaglutide and tirzepatide.How it works: VK2735 acts on both GLP-1 and GIP, similar to tirzepatide (the active ingredient in Mounjaro and Zepbound).It's being tested in pill form as well as a once-weekly injection.Current research: A <a target="_blank" class="" href="https://ir.vikingtherapeutics.com/2024-02-27-Viking-Therapeutics-Announces-Positive-Top-Line-Results-from-Phase-2-VENTURE-Trial-of-Dual-GLP-1-GIP-Receptor-Agonist-VK2735-in-Patients-with-Obesity">mid-stage trial</a> found patients on VK2735 lost an average of 14.7% of their body weight (about 32 pounds) by 13 weeks.It hasn't been directly tested against other medications but the results are comparable to what we've seen in trials of semaglutide (Ozempic, Wegovy) after 68 weeks. That suggests similar weight loss but in a fraction of the time.Timeline: Viking Therapeutics <a target="_blank" class="" href="https://ir.vikingtherapeutics.com/2024-10-23-Viking-Therapeutics-Reports-Third-Quarter-2024-Financial-Results-and-Provides-Corporate-Update">recently announced</a> it would meet with the FDA about the end of Phase II for VK2735 injections before 2025. The oral form of VK2735 is expected to enter Phase II trials by the end of this year, too.<h2 id="77bb7c6c-1d1d-424d-aa59-728b114c2d15">Eli Lilly is racing to get the first weight-loss pill on the market</h2>Why it's interesting: Eli Lilly may beat Viking Therapeutics to get the first oral GLP-1 to market.Their drug orforglipron appeals to patients who can't or don't want to use injected medications. It is also expected to be cheaper, since it's easier to produce (orforglipron isn't a <a target="_blank" class="" href="https://www.businessinsider.com/peptides-growth-hormone-hgh-new-health-fad-2023-9">peptide</a> like other GLP-1 drugs).However, the clock is ticking.Novo Nordisk already has an oral semaglutide to treat type 2 diabetes, sold under the brand name Rybelsus, and they're trialing a <a target="_blank" class="" href="https://www.businessinsider.com/ozempic-pill-semaglutide-helped-overweight-people-lose-weight-in-trial-2023-5">high-dose version of that pill that could be approved for weight loss</a>.How it works: The active ingredient in the daily pill is a small molecule which slow digestions and manages blood sugar and insulin, similar to semaglutide (Ozempic, Wegovy).Current research: <a target="_blank" class="" href="https://www.nejm.org/doi/full/10.1056/NEJMoa2302392">Results from Phase II trials</a> found that people taking orforglipron lost between 9.4% and 14.7% of their body weight, on average, in 36 weeks.Timeline: Current <a target="_blank" class="" href="https://clinicaltrials.gov/study/NCT05869903">late-stage trials</a> are expected to last into 2027.<h2 id="1e386d6d-423a-4b83-b3c7-70231a9cd219">Novo Nordisk is touting a stronger alternative to Ozempic that may be easier to produce at scale</h2>Why it's interesting: CagriSema is a once-weekly injection that combines semaglutide (active ingredient in Ozempic and Wegovy) with a compound targeting another hormone, cagrilintide. This combination is expected to help people lose significantly more weight than semaglutide alone, Novo Nordisk says.How it works: Cagrilintide mimics the effects of a naturally-occurring hormone to regulate appetite and digestion and lower blood sugar. CagriSema adds it to the already-popular drug semaglutide, which itself helps manage hunger and blood sugar levels.Novo's chief financial officer said in an earnings call that it would source cagrilintide from a third-party company, which could help with manufacturing. Supply issues and <a target="_blank" class="" href="https://www.businessinsider.com/buy-compounded-semaglutide-online-risks-wegovy-ozempic-2023-1">shortages</a> have previously hampered its semaglutide products.Current research: One <a target="_blank" class="" href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01163-7/abstract">early study</a> found patients lost more weight on CagriSema (about 15% weight loss over 32 weeks) than either semaglutide or cagrilintide alone.A Novo Nordisk executive told <a target="_blank" class="" href="https://www.reuters.com/business/healthcare-pharmaceuticals/novo-nordisk-says-its-experimental-drug-cagrisema-has-similar-side-effects-2024-11-06/">Reuters</a> that projections from the data suggest it could help people lose even more, up to 25% of their weight, over a longer timeline.Timeline: Phase III clinical trials for Cagrisema are ongoing and slated to last until late 2025. The drug could be available in 2026.<h2 id="f9e2452f-a8fe-47e5-a61d-209a3b2b28b3">A longer-lasting monthly shot from Amgen</h2>Why it's interesting: MariTide, from biotech company Amgen, could be a much longer-lasting treatment than current drugs. It only needs to be injected once a month — or even less frequently — compared to the once-weekly requirement for semaglutide and tirzepatide."Longer-acting versions of GLP-1 medications offer the potential for greater convenience and potentially improved adherence and sustained use over time," McGowan said.The catch is whether side effects might last longer, too.How it works: MariTide is similar to Mounjaro and Zepbound because it mimics GLP-1 and GIP hormones.The difference is that MariTide dials down GIP receptor activity. Amgen says this makes it easier for the body to burn fat."This is fascinating because it appears that both enhancing and opposing the GIP receptor influence weight regulation, which speaks to how little is still known about the actual weight-regulating mechanism of certain gut hormones," McGowan said.Current research: Patients in a <a target="_blank" href="https://affiliate.insider.com?h=e053792e27a615fb7dda56aa0745b0c87c4f95e380ec169abcf45f1d1b11336c&amp;postID=673380d5d057d3e5c5d03443&amp;postSlug=upcoming-glp1-weight-loss-drugs-to-watch-2024-11&amp;site=bi&amp;u=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs42255-023-00966-w">small early-stage study</a> lost 14.5% of body weight on average in 12 weeks. Those who got just a single dose lost an average 8.2% of their body weight.Timeline: Data from Phase II trials is <a target="_blank" class="" href="https://www.amgen.com/newsroom/press-releases/2024/10/amgen-reports-third-quarter-2024-financial-results">expected later this year</a>, and planning is underway for Phase III trials.

5 new weight-loss drugs to watch in the fight for the next Ozempic

<ul class="summary-list"><li>Jeff Horton started drinking at the age of 12. He became dependent on alcohol in his early 20s.</li><li>He wasn't present for his son as he grew up since he could only think about his next drink.</li></ul>This as-told-to essay is based on a conversation with Jeff Horton, 50, a development operations manager from Richmond, Virginia. It has been edited for length and clarity.I wasn't present for my son, Joel, when he was growing up. He'd ask me if I wanted to go to the park. "No, let's stay home and watch TV," I'd always say. I'd sit in the chair with a beer in my hand — and keep going all afternoon, progressing to hard liquor like whisky. I'd often black out.I've been sober since 2021, thanks to a medicine that made my alcohol craving disappear, and I get to be present as a grandfather in a way I never was as a dad. <h2 id="d67e68fd-e0a3-49c6-a885-f014d13d8011">Alcohol has been a problem since I was a tween</h2><a target="_blank" class="" href="https://www.businessinsider.com/guides/health/conditions-symptoms/signs-of-alcoholism">Alcohol was a problem </a>for me from the age of 12. When I was in fifth grade, I felt like I didn't fit in. But I eventually found my group in the kids who hung out at the back of the school and smoked cigarettes.It wasn't long before I had my first taste of beer. Then it was whiskey, vodka, and gin — anything we could get our hands on as young teens. We'd stand outside the liquor store and ask an adult to buy bottles for us. Or the store owners would just sell it to us.In high school, I'd drink at parties and friends' houses. My parents found out and would ground me. But I'd find a way to drink in secret in my room.At 18, they told me to either get out of the house or go to rehab. <a target="_blank" class="" href="https://www.businessinsider.com/drew-barrymore-teen-drug-rehab-center-mothers-day-2023-5">They paid for a rehab center</a> in Florida. I had one relapse but stayed sober for over four years.<h2 id="135ac0e4-f076-4b38-91d2-83c663dbdf6a">I was an obnoxious person</h2>Then, in the mid-90s, one of my friends died from a heart attack. He was in his 20s. I went to his funeral and met up with my old friends that I used to drink with. I couldn't resist the temptation and fell back into bad habits.I married my wife, Suzanna, in 2002. She meant everything to me. But on our <a target="_blank" class="" href="https://www.businessinsider.com/why-you-should-go-on-honeymoon-before-getting-engaged-2024-1">honeymoon in Jamaica</a>, I got completely blitzed. I had to be carried off to my room. She was embarrassed.I caused a lot of scenes. We'd go to parties where I'd get drunk, flirt with other women, and say inappropriate things. I was an obnoxious, horrible husband who'd yell at Suzanna and then blackout. The next morning, I couldn't remember a thing.Things got progressively worse. I started drinking during my workday. The pandemic meant I was working from home, which made it harder. <a target="_blank" class="" href="https://www.businessinsider.com/how-to-make-own-alcohol-at-home-cocktail-recipes">I brewed my own beer</a> in the basement, where I'd hang out on my own.In early 2021, our marriage was so rocky that we decided to get divorced. We each spent $10,000 on lawyers, but somehow, Suzanna, now 51, forgave me. We worked hard on our marriage and called off the divorce.<div type="image" title="A middle-aged man on a dock holding up a fish he just caught." height="2268" width="3024" msid="115344596" hostid="261" sizebytes="501158"></div>That summer, I blacked out once again. It frightened me so much that I knew I had to get ahold of myself. I was on the verge of losing my job or dying. I'm 5ft 11in and weighed 260 pounds. I'd be drenched in sweat doing simple tasks like picking up leaves. My blood pressure and cholesterol levels were dangerously high. I talked to HR and the CEO of my company. I'd worked there for 30 years, and they care about me. I asked if I could take a monthlong leave to go to rehab. They told me to get better and come back when I was ready. So, I detoxed at a 30-day residential program at Mount Sinai Wellness Center in Dahlonega, Georgia. I had group sessions and individual counseling. I picked up the tools to stay sober.<h2 id="045f0686-5bd3-4e35-ae7f-80ae21e2ca07">I no longer crave alcohol</h2>Still, I knew I needed ongoing support. In August 2021, <a target="_blank" class="" href="https://www.vivitrol.com/alcohol-dependence?utm_medium=cpc&amp;utm_source=google&amp;utm_campaign=2022+Branded&amp;utm_term=vivitrol_exact&amp;utm_content=Brand+-+Exact&amp;gclsrc=aw.ds&amp;&amp;gclsrc=aw.ds">the doctors prescribed me Vivitrol</a>, a medication that helps reduce alcohol dependence. They explained how it affects the opioid pathways to the brain, so you don't get that "buzz" from drinking.It made me not want to drink at all. It lost its appeal because it didn't have the same effect on me. I told Suzanna to get rid of my distilling equipment in the basement.I have monthly intramuscular shots at a local pharmacy. They inject the extended-release drug between my buttocks and hips.The benefits have changed my life. I have no inclination to drink, and <a target="_blank" href="https://www.businessinsider.com/how-calorie-counting-helped-me-improve-my-relationship-with-food-2019-9">the calories I've saved </a>have helped me lose 70 pounds. It's turned my metabolism around. I was a 44-inch waist, and now I'm a 34. I've gone from an XXL to a large. I've got more energy for my favorite sport, fishing.Suzanna and Joel, 32, are proud of me. Joel's wife, Harley, gave birth to our beautiful grandchild, Nora, two years ago. Thank God she has never seen me drunk — and she never will. People tell me I'm a great, hands-on granddad. I'm very happy to play with Nora for hours.I feel like I'm making up for the time I didn't spend with Joel when he was young. I treasure every moment.Do you have an interesting story to share with Business Insider about making a life change? Please send details to <a target="_blank" href="mailto:jridley@insider.com">jridley@businessinsider.com</a>

I got sober thanks to a monthly shot of a drug that helps stop my craving for alcohol. I lost 70 pounds in the process.

<ul class="summary-list"><li>Mike Tyson, 58, is set to fight Jake Paul, 27, at Dallas' AT&amp;T stadium on Friday.</li><li>Tyson's training includes early morning cardio, strength workouts, and affirmations.</li></ul><a target="_blank" href="https://www.businessinsider.com/mike-tyson-net-worth-career-earnings-money-2022-8">Mike Tyson</a>, 58, is preparing to fight <a target="_blank" href="https://www.businessinsider.com/jake-paul-controversies-timeline-looting-scandals-racist-slurs-drama-2020-6">Jake Paul</a>, 27, on Friday at 8pm Eastern Time at Dallas' AT&amp;T stadium.Paul, a YouTuber who has been boxing professionally for four years, will take on two-time heavyweight world champion Tyson in eight two-minute rounds in front of a live audience of 70,000 people and up to 280 million <a target="_blank" class="" href="https://www.businessinsider.com/mike-tyson-vs-jake-paul-heavyweight-champion-fighting-youtuber-how-2024-11">watching live via Netflix</a>.While Tyson is more experienced, he has not fought professionally for 19 years, since he lost to Kevin McBride in 2005.When asked on Tuesday after a public workout what he's learned during his training for Friday's fight, <a target="_blank" href="https://www.theguardian.com/sport/2024/nov/13/mike-tyson-vs-jake-paul-fight-preview-feature-november-15">Tyson said</a>: "That I'm tougher than I believed I was because, when I agreed to this fight and started training, I thought: 'What the fuck was I thinking of?' But I've finished the process. The fight is the party. All the hard work is done."Here's what we know about how Tyson has been training for the fight.<div type="image" title="Mike Tyson standing with boxing gloves." height="2389" width="3816" msid="115341346" hostid="261" sizebytes="468404"></div><h2 id="f4416611-3a68-49f2-a6e5-3db61607b98d">Tyson trains early in the morning</h2>On Wednesday's episode of "<a target="_blank" href="https://www.youtube.com/watch?v=KCziU_PNudc&amp;t=64s">The Record with Greta Van Susteren</a>," Tyson described his training regime: "Four o'clock in the morning, doing an hour of cardio, then take a bath, wake up at one o'clock, go to the gym, train eight rounds boxing, hit the bag, maybe, then I train with my strength and conditioning coach, and then I work again. It's just an all-day process."He added that sometimes training is fun, other times it's difficult.Tyson has been posting snippets from his training on Instagram, showing himself building both strength and cardiovascular fitness.He can be seen doing air bike workouts; bodyweight <a target="_blank" href="https://www.businessinsider.com/how-to-squat-build-muscle-strength-trainer-tips-2022-5">squats</a>, bench presses, shoulder presses, lying medicine ball throws, rows, <a target="_blank" href="https://www.businessinsider.com/halle-bailey-little-mermaid-built-core-toned-shoulders-2023-6">neck strengthening exercises</a>, and bicep curls; and of course throwing punches in the ring.<h2 id="75072da0-bba6-4a18-b858-d53f767cfe24">Tyson quit being vegan</h2>While Tyson used to be a vegan, he now enjoys eating meat when training for a fight, he told Van Susteren."After a fight, I won't eat meat any more," he said, adding that he likes the way he feels without it.<h2 id="949aa2d3-42b4-4534-9621-a0225eb494df">Affirmations are key for Tyson</h2>Fostering a positive mindset is a key part of Tyson's mental training."There's nothing stronger than the power of belief, affirmations, saying wonderful things about yourself, whatever you're willing to accomplish, you foresee it before it even happens," he said in a recent <a target="_blank" href="https://www.instagram.com/p/DCX8ktmMnKC/">Instagram video</a>. "You talk about it, you think about it constantly. That's the beginning of the mindset of winning."<h2 id="20f71219-daec-46e3-b121-e269ae75c999">Jake Paul eats luxury protein</h2>Tyson's opponent, Jake Paul, has been training hard too.Speaking to <a target="_blank" href="https://www.menshealth.com/fitness/a61638754/jake-paul-gym-fridge-workout/">Men's Health</a> in July, the YouTuber turned boxer said he trains twice a day, five to six days a week. His first session of the day is boxing and drills, while the second is strength and conditioning or track, he said.As for his diet, Paul said he used to love fast food but now eats mostly whole foods and prioritizes protein, especially luxury cuts like wagyu beef and smoked salmon.To calm his mind, Paul meditates and goes on beach walks, he said.

How Mike Tyson, 58, is preparing to fight Jake Paul, who is almost half his age

<ul class="summary-list"><li>Josh Brolin says he uses nicotine pouches almost all the time, including while he's asleep.</li><li>He switched to nicotine pouches after getting cavities from nicotine lozenges, he said on a podcast.</li></ul>Josh Brolin loves his <a target="_blank" class="" href="https://www.businessinsider.com/zyn-pouches-become-popular-some-workers-2024-3">nicotine pouches</a> and he's not afraid to show it.On Thursday's episode of the "<a target="_blank" class="" href="https://www.wtfpod.com/podcast/episode-1591-josh-brolin">WTF with Marc Maron</a>" podcast, the "Dune" actor spoke about his nicotine habits with host Marc Maron.Brolin said he switched to using nicotine pouches after he got cavities from nicotine lozenges."They go in two seconds, but they taste like gasoline, and they got a punch to them," Brolin said. "But I used to keep them up between my gum and my tooth line. I got seven cavities."Evidence has suggested that even sugar-free nicotine lozenges can cause tooth decay, the primary cause of cavities, according to a case report in the National Library of Medicine.Now, Brolin says he's using the nicotine pouches almost all the time, even at night."My wife would hear this in the middle of the night," Brolin said on the podcast, while mimicking chewing noises. "I don't even know I'm doing it, I'm asleep. I have a pouch in my lip, and I'm not fucking lying, 24 hours a day."Nicotine pouches are small microfiber pouches that contain a powdered mix of nicotine, flavorings, and other ingredients, per the CDC. The pouches are usually placed between the user's lip and gums, where the nicotine is absorbed through the gums and lining of the mouth.While often used as an alternative to nicotine and tobacco products like vapes and cigarettes, the FDA has not approved any nicotine pouches to help people quit smoking, per the CDC.Zyn is one such nicotine pouch brand that has seen soaring popularity in recent years, despite being available for sale in the US since 2014.Shipments of Zyn's nicotine pouches in 2023 <a target="_blank" class="" href="https://www.businessinsider.com/zyn-nicotine-pouches-huge-increase-us-shipments-2024-2">were up 62% year over year</a>. The brand's nicotine pouches have become a favorite among <a target="_blank" class="" href="https://www.businessinsider.com/wall-streets-underground-drug-abuse-culture-cocaine-adderall-zyn-mushrooms-2024-1">Wall Street traders, who say they use it to keep their energy up at work</a>, as well as <a target="_blank" rel="" href="https://www.businessinsider.com/chuck-schumer-nicotine-zyn-republican-right-wing-2024-1">political conservatives</a> such as GOP lawmakers.A representative for Brolin did not immediately respond to a request for comment sent by Business Insider outside regular office hours.

Josh Brolin says he uses nicotine pouches '24 hours a day' and sleeps with them in his mouth

<ul class="summary-list"><li>Americans' diets have remained largely unchanged since 1999, according to a new study.</li><li>Meals remain high in processed foods that can increase a person's risk of disease.</li></ul>Americans are eating healthier than in previous years, but they still have a long way to go, according to a researcher who studies food as medicine.Dr. Dariush Mozaffarian, director of the Food is Medicine Institute at Tufts University in Boston, co-authored a study on the quality of nearly 52,000 American adults' diets between 1999 and 2020. The <a target="_blank" href="https://www.acpjournals.org/doi/10.7326/M24-0190">results</a> were published online Tuesday in the Annals of Internal Medicine.Mozaffarian and his co-author, Junxiu Liu, examined data from the National Health and Nutrition Examination Survey and found that the American diet has remained nearly the same over the past two decades. Between 1999 and 2020, 10.5% of study participants transitioned from "poor" diets to healthier diets with more fruits, vegetables, and whole grains and less sodium, processed meat, and saturated fat. But only 1% of study participants ate an "ideal" diet — 4 to 5 cups of fruits and vegetables daily, plus beans, whole grains, and nuts — during that same time period."People often ask me, 'Well, if the diet's slowly improving, why is obesity and diabetes still going up?' It's still going up because only 1.58% of Americans have an ideal diet. We still have a long way to go," Mozaffarian told <a target="_blank" href="https://www.cnn.com/2024/06/17/health/improve-diet-quality-tips-wellness/index.html">CNN</a>."We have stalled as a nation — and that does not bode well for our health. If I was grading America on its diet, I'd give it a D—just up from an F," Mozaffarian said.<h2 id="645b3920-d5b9-4d14-868f-c48fe2d6ed79">Why are Americans failing in the diet department?</h2>Typically, the American diet consists of <a target="_blank" href="https://www.businessinsider.com/what-is-processed-food-2019-5">ultra-processed foods</a> and foods high in salt and sugar. These foods can increase a person's risk of <a target="_blank" href="https://www.businessinsider.com/cancer-prevention-lifestyle-changes-dietitian-advice-healthy-eating-2024-5">cancer</a>, <a target="_blank" href="https://www.businessinsider.com/scientists-making-ultra-processed-foods-healthier-in-major-new-study-2024-6">heart disease, stroke, and early death</a>Accordingng to Heidi Silver, a registered dietitian and director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core at Vanderbilt University Medical Center in Nashvil, factors like food insecurity and poverty have contributed to the overall lack of improvement in peoples' diets over the last two decadesle."Food insecurity affects diet quality via lower consumption of healthier foods, especially those that are more expensive, don't have a long shelf life and don't provide enough volume to fill a hungry child," Silver told <a target="_blank" href="https://ca.news.yahoo.com/american-diets-improve-remain-poor-210006855.html?guccounter=1&amp;guce_referrer=aHR0cHM6Ly93d3cuZ29vZ2xlLmNvbS8&amp;guce_referrer_sig=AQAAAIxQY8jqfhJZ3nx6GI2CtFozsjcKqPHfZhqg_rC9m-24aGDD3TjXfwdJHkeL65FOYo0wJAreBHfWpuUPOMTPw-43gndFGf3yxht1rIDsCj0IE3tNCRJY2szyhtRlrWX0oGzNtmVtXPIHHiiQjGoJPzLm36OE9ISBfPoUBCvEg_ge">Yahoo</a>.These systemic limitations can make it difficult for food-insecure populations like Black people, older people, and low-income people to make lasting diet changes.<h2 id="8710d05f-4de3-497e-a0da-5d101197b1d3">Simple diet tweaks could help reduce health risks</h2>For those seeking simple and inexpensive ways to improve their diets, removing sugary drinks is a good first step, according to Dr. Gregory Katz, a cardiologist at NYU Langone."<a target="_blank" href="https://www.businessinsider.com/cardiologist-shares-easy-way-avoid-biggest-calorie-heart-health-mistake-2024-6">Drinking calories and drinking alcohol</a> are the biggest modifiable risk factors. The number of people I see drinking 500 calories a day blows my mind," Katz told Business Insider's Gabby Landsverk. "Just because it's simple doesn't make it easy."Katz suggested doing away with soda, juice, sugar-laden coffee drinks, and cocktails and replacing them with unsweetened tea or water flavored with a splash of juice or flavored with citrus.Aiming to <a target="_blank" href="https://www.businessinsider.com/harvard-researcher-healthy-swaps-to-cut-processed-foods-improve-brain-gut-health-2024-6">swap out two servings of processed foods</a> each week is another strategy that doesn't involve overhauling your entire diet, according to Dr. W. Taylor Kimberly. Kimberly, a professor of neurology at Harvard Medical School and the senior author of a recent <a target="_blank" href="https://www.neurology.org/doi/10.1212/WNL.0000000000209432">study</a> linking ultra-processed foods to health risks like dementia and stroke.You could, for example, swap French fries for a baked sweet potato or nosh on nuts and carrots instead of cookies and crackers.Kimberly said that a good rule of thumb is to prepare meals at home as much as possible."If you look at it and think, that could be made in my kitchen, that's a good indicator," he said.

Americans are just about failing when it comes to nutrition, says a food-as-medicine researcher. A few simple diet tweaks could help.

<ul class="summary-list"><li>Eva Longoria shared wellness practices that she lives by.</li><li>Longoria, who will turn 50 in March, added that she's 'excited' to age.</li></ul><a target="_blank" class="" href="https://www.businessinsider.com/eva-longoria-john-wick-investments-money-worth-2024-10">Eva Longoria</a>'s 50th birthday is fast approaching, and she's more than ready for the milestone.In an interview with <a target="_blank" class="" href="https://www.marieclaire.com/culture/eva-longoria-nov-2024-cover/">Marie Claire</a> published on Wednesday, the "<a target="_blank" class="" href="https://www.businessinsider.com/then-and-now-desperate-housewives-2019-6">Desperate Housewives</a>" actor shared a list of wellness practices she lives by."I'm <a target="_blank" class="" href="https://www.businessinsider.com/daily-cold-plunge-at-home-benefits-not-worth-it-review-2024-5">cold-plunging</a>; I've got <a target="_blank" class="" href="https://www.businessinsider.com/guides/beauty/red-light-therapy">red lights</a> on; I strength train with weights; I meditate; I'm journaling," she said. "I wake up with the sun; I'm doing the grounding; I have an <a target="_blank" class="" href="https://www.businessinsider.com/oura-smart-ring-review-why-wont-solve-back-to-work-2021-9">Oura ring</a> to track deep sleep; I'm taking <a target="_blank" class="" href="https://www.businessinsider.com/guides/health/diet-nutrition/magnesium-benefits">magnesium</a> and other supplements.""I'm doing everything. Not because I don't want to age but because I do want to age," said Longoria, who turns 50 in March."For me, age is just a number, but I'm excited," Longoria added. "I refuse to believe my greatest success is behind me."In 2016, Longoria told "<a target="_blank" href="https://www.thecut.com/2016/04/eva-longoria-workout-routine-diet.html">The Cut</a>" that people should prioritize their time and efforts toward wellness."Everything is about balance. I think people waste more time than they think. They think, 'I don't have time to <a target="_blank" class="" href="https://www.businessinsider.com/guides/health/mental-health/how-to-meditate">meditate</a>,' or 'I don't have time to work out,' and yet they have time to be on Instagram for 30 minutes — like, that could have been their meditation session," she said.For Longoria, exercise is not just something she does. "It's part of my life," she told "<a target="_blank" href="https://www.today.com/health/eva-longoria-workout-rcna158708">Today</a>" in June.Longoria, who has a bachelor of science degree in kinesiology from Texas A&amp;M University-Kingsville, said she usually does <a target="_blank" class="" href="https://www.businessinsider.com/personal-trainer-mom-older-strength-training-habit-five-years-longevity-2024-11">strength training</a> and trampoline cardio. She also said she eats in moderation and has no hard and fast rules for restricting her diet."I'm lucky that I gravitate to healthy things. I love fish and vegetables. I love chicken and vegetables. I love beef and vegetables," she said.A representative for Longoria did not immediately respond to a request for comment from Business Insider sent outside regular business hours.<h2 id="3c93f288-1cc0-43d5-b693-4d1c8bb07ea9">Simple habits to age well</h2>As humans live longer than ever, <a target="_blank" class="" href="https://www.businessinsider.com/raadfest-cheat-death-longevity-loma-linda-blue-zone-2023-9">antiaging procedures</a> — from <a target="_blank" class="" href="https://www.businessinsider.com/stem-cell-injections-knee-joints-longevity-wellness-industry-bryan-johnson-2024-7">stem-cell injections</a> to <a target="_blank" class="" href="https://www.businessinsider.com/what-is-plasma-exchange-therapy-why-is-it-longevity-treatment-2024-10">plasma exchange therapy</a> — are all the rage among <a target="_blank" class="" href="https://www.businessinsider.com/inside-bryan-johnson-dont-die-summit-singapore-longevity-health-biohacking-2024-10">wealthy longevity-seekers</a>.But the key to aging well may lie in simple everyday habits. In November, <a target="_blank" href="https://www.businessinsider.com/longevity-tips-nobel-prize-scientist-cycles-daily-2024-11">Venki Ramakrishnan</a>, a Nobel laureate and the author of "Why We Die," shared three habits he lives by: eating nutritious foods in modest portions, cycling every day, and getting eight hours of good-quality sleep every night.<a target="_blank" class="" href="https://www.businessinsider.com/how-to-get-better-sleep-millionaire-advice-2024-6">Sleep</a>, in particular, is "a way of resetting things and regenerating things," he said.Like Ramakrishnan, Mary Ní Lochlainn, a researcher in geriatric medicine at King's College London, includes <a target="_blank" class="" href="https://www.businessinsider.com/scientist-healthy-aging-research-eats-works-out-longevity-resistanc-training-2024-10">exercise in her daily routine</a>. Besides cycling, she adds resistance training to build muscle mass and prevent frailty. She also consumes vitamin D supplements and practices <a target="_blank" class="" href="https://www.businessinsider.com/intermittent-fasting-benefits-and-risks-for-longevity-weight-loss-cancer-2024-4">intermittent fasting</a>, she told BI earlier this month.It's also important that these habits are picked up early. "People think 'I'll do all of that later,' but actually, it's much better to just be doing it now," she said.

Eva Longoria, 49, says she's doing 'everything' to age well — from cold-plunging to red-light therapy

<ul class="summary-list"><li>Robert F. Kennedy Jr. is President-elect Trump's pick to lead the US Department of Health and Human Services.</li><li>RFK has been vocal in his opposition to fluoride in tap water, and vaccine mandates.</li></ul>"Make America Healthy Again" is the new healthcare slogan from Robert F. Kennedy Jr., President-elect Trump's new pick for Health and Human Services secretary.Trump has said in the past that he'll let Kennedy "go wild" on health. <a target="_blank" class="" href="https://www.businessinsider.com/trump-robert-f-kennedy-jr-rfk-department-health-human-services-2024-11">As head of HHS</a>, Kennedy will be responsible for overseeing many federal health agencies, including the National Institutes of Health (NIH), Centers for Disease Control and Prevention (CDC), and the Food and Drug Administration (FDA).Kennedy is a former environmental justice lawyer, who pivoted in recent years to running an anti-vaccine charity. He ran for president himself as an independent candidate in the 2024 race, before dropping out to join Trump's inner circle.Here's what we know so far about Kennedy's public health philosophy, and what kinds of reforms he might fight for in 2025 and beyond.<h2 id="79c799a9-93e2-4522-9d2c-5e71f4588e27">Kennedy's MAHA ideas include shifts in some basic public health protocols</h2><div type="image" title="tap water" height="4000" width="6000" msid="115314143" hostid="261" sizebytes="655952"></div>He has said he would:<ul><li>Lobby against <a target="_blank" href="https://www.businessinsider.com/fluoride-in-water-why-it-is-controversial-risks-benefits-2024-11">fluoride</a> in the water system</li></ul>Though the federal government isn't in charge of this issue, Kennedy has made it clear he's not in favor of fluoridated water, and would encourage water districts to get rid of it.<ul><li>Get rid of vaccine mandates</li></ul>Kennedy, previously at the helm of one of the biggest <a target="_blank" href="https://www.businessinsider.com/robert-f-kennedy-jr-views-vaccines-autism-testing-debunked-2023-7">anti-vaccine charities</a>, has been careful in recent interviews to say that he wouldn't ban vaccines."I'm not going to take away anybody's vaccines," he told <a target="_blank" href="https://www.nbcnews.com/politics/2024-election/trump-win-rfk-jr-says-wont-take-away-anybodys-vaccines-rcna178955">NBC</a> after Trump's election. "If vaccines are working for somebody, I'm not going to take that away. People ought to have choice."Like with fluoride, Kennedy can't actually control which routine vaccines kids get for school, that task is largely up to each individual state to decide. But he could change which vaccines federal employees are required to take, or have an influence on US <a target="_blank" href="https://www.hhs.gov/immunization/who-and-when/military-members/index.html">military</a> vaccine protocols.His stance has public health officials spooked, because part of what makes vaccination work so well is the fact that nearly everyone in our society does it."We have a very short memory of what it is like to hold a child who has been paralyzed with polio, or to comfort a mom who lost their kid from measles," CDC Director Mandy Cohen <a target="_blank" href="https://kffhealthnews.org/morning-breakout/cdc-fda-officials-warn-kids-could-die-from-rfk-jr-s-anti-vaccine-stance/">said</a> on Wednesday at a conference in Washington DC. "I don't want to have to see us go backward in order to remind ourselves that vaccines work."<ul><li>Encourage people to use more "functional medicine" and make "alternative" healthcare mainstream</li></ul>Kennedy has said he'd push for more coverage of functional medicine, and devote 50% of the National Institutes of Health budget to "preventive, alternative and holistic approaches to health." Typically, visits to functional medicine doctors, and the kinds of tests and treatments they provide for health concerns like allergies, gut issues, or disease prevention, are not necessarily covered by traditional health insurance.He also floated the idea of giving every American a Health Savings Account for medical spending, which is basically a debit card-like alternative to a traditional private healthcare plan. With a HSA, you put money you earn into a tax-free account to use for healthcare expenses like doctor's visits and prescriptions, instead of paying monthly premiums to insurance.In a Wall Street Journal <a target="_blank" href="https://www.wsj.com/opinion/trump-can-make-america-healthy-again-rfk-jr-reforms-chronic-disease-crisis-a9b4b8c0">opinion piece</a> he published in September, Kennedy also said in wants to "reform the Prescription Drug User Fee Act," a move he hopes would boost competition in the drug market.<h2 id="a747df1e-458d-41c6-be6f-aed4a6408629">A big chunk of the other ideas Kennedy has for improving human health have to do with our nutrition and fitness</h2><div type="image" title="fruit loops" height="3024" width="4032" msid="115314148" hostid="261" sizebytes="1059522"></div>These are aimed at improving rates of chronic health issues like obesity and type 2 diabetes."I don't think you have to be too smart to say we have a chronic disease crisis going on in this country that starts in childhood with terrible diets," FDA Commissioner Robert Califf <a target="_blank" href="https://www.statnews.com/2024/11/12/fda-commissioner-califf-trump-election-rfk-jr-public-health-food-nutrition/">recently told</a> STAT. "There is work that needs to be done."Some of Kennedy's biggest ideas on this front include:<ul><li>Getting rid of artificial food coloring and banning some additives and chemicals</li></ul>The European Union has banned specific dyes like red #40, which studies have linked to hyperactivity and neurobehavioral issues like ADHD in some kids. California is currently trying to copy the strategy, with limited success.On the campaign trail with Trump, Kennedy has made Fruit Loops the poster child for this issue, pointing out how the US version contains more artificial colors and additives than versions sold elsewhere.<ul><li>Ending FDA scrutiny of things like raw milk and supplements</li></ul>Kennedy has claimed that the FDA is battling a "war on public health" and is suppressing the use of anything "that advances human health and can't be patented by Pharma."<a target="_blank" href="https://x.com/RobertKennedyJr/status/1849925311586238737">On X</a>, he recently listed out the items he feels the agency is overregulating: "psychedelics, peptides, stem cells, raw milk, hyperbaric therapies, chelating compounds, ivermectin, hydroxychloroquine, vitamins, clean foods, sunshine, exercise, nutraceuticals."The FDA does not tell consumers that they can't drink raw milk, take supplements, or enjoy sunshine and exercise. Rather, the agency often issues warnings about the health hazards of certain items. Raw milk increases your risk of developing E. coli, and in rare cases can be fatal.The FDA is also responsible for ensuring drugs are safe and effective before they are put on the market. It doesn't approve dietary supplements, but the agency warns consumers when it finds contamination in our supplements and food supply.<ul><li>Changing the rules for food stamps</li></ul>Kennedy doesn't want people to use SNAP benefits to buy ultra-processed foods. He has also said he wants to ban ultra-processed foods in school lunches.<ul><li>Getting rid of conflicts of interest and ties to food and drug companies at various federal agencies</li></ul>Kennedy said he'd work to ensure members of the Dietary Guidelines Advisory Committee have no connections to food or drug companies. He also wants to reform farm subsides, cutting back on corn and soy.<ul><li>Requiring medical students at federally-funded institutions to take nutrition classes</li></ul>Doctors only tend to receive about <a target="_blank" href="https://theconversation.com/diet-related-diseases-are-the-no-1-cause-of-death-in-the-us-yet-many-doctors-receive-little-to-no-nutrition-education-in-med-school-236217">three hours</a> of nutrition education during medical school.<ul><li>Coming up with some new "presidential fitness standards"</li></ul>"My uncle John F. Kennedy was right in 1960 <a target="_blank" href="https://archive.org/stream/the-soft-american-kennedy/The%20Soft%20American%20-%20Kennedy_djvu.txt">when he wrote</a>, 'The physical vigor of our citizens is one of America's most precious resources.'" Kennedy recently wrote in an op-ed.<h2 id="314334a6-b0ff-45de-83d9-23c9a86f7b1d">He also has a couple of ideas for Big Pharma reform</h2>Kennedy's said he wants to:<ul><li>Negotiate drug prices</li></ul>This is something a lot of countries do, but the US does not. Lots of politicians (like Bernie Sanders) have said this is something they want to do. In practice, it's been <a target="_blank" class="" href="https://www.sanders.senate.gov/press-releases/news-sanders-statement-on-medicare-negotiating-drug-prices/">pretty hard</a>.<ul><li>Crack down on pharmaceutical ads</li></ul>Again, the US is one of the few places in the world where drugmakers can sell commercials that run in primetime TV and market drugs directly to consumers.<h2 id="d5d943f7-f1ea-4ec2-9259-d9fd87aa5c73">It's pretty unclear how realistic this all is</h2>A lot of what Kennedy wants to do for public health is in conflict with Project 2025, which would basically deregulate the entire food industry.The Project 2025 plan, drafted by a consortium of conservative DC think tanks, would lift federal restrictions on sugar, get rid of dietary guidelines altogether, eliminate mandatory food labeling, and defund school lunches for kids.

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