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<ul><li>Indian-origin doctor, <keyword id="13592230" type="General" weightage="80" keywordseo="diljeet-gill" source="Orion">Diljeet Gill</keyword> used a new technique to make skin cells younger.</li><li>The research included 3 middle-aged people (50 years old).</li><li>Earlier, <keyword id="1409162" type="General" weightage="80" keywordseo="shinya-yamanaka" source="Orion">Shinya Yamanaka</keyword> genetically reprogrammed the mouse skin cells. </li></ul>Diljeet Gill, a postdoctoral candidate at the Babraham Institute in Cambridge and his colleagues have developed a way to reverse the ageing process in skin cells by 30 years. The method was published on 8 April in the journal eLife <a href="https://elifesciences.org/articles/71624">‘Multi-omic rejuvenation of human cells by maturation phase transient reprogramming’. </a> The research was done by using ‘<keyword id="13677889" type="General" weightage="20" keywordseo="maturation-phase-transient-reprogramming" source="Orion">maturation phase transient reprogramming</keyword>’ to fibroblasts which is a common type of skin cell. The team took skin cells from three middle-aged donors, who aged around 50 years old. Once the research was completed, they compared them to younger skin cells from donors aged 20 to 22. They found skin cells were similar to younger cells, genetically and chemically. Further, the team also found that the techniques had affected genes related to age-related diseases such as cataracts and Alzheimer's. In addition, Gill and his team also examined the behaviour of skin cells that if why could also act like younger skin cells. According to them, when they wounded a layer of cells they found that the rejuvenated cells quickly moved to fill the gap similar to the behaviour of younger skin cells. This is not the first successful research on de-ageing cells. Earlier, Shinya Yamanaka, a Nobel prize-winning stem cell researcher, genetically reprogrammed the mouse skin cells and turned them into induced pluripotent stem cells, or iPSCs, back in 2006. These cells type had the potential to form any cell type in the body. Yamanaka's method took 50 days and completely reprograms cells to the biological age of an embryo. Gill's method only took 13 days. In a statement, Gill said, “Our results represent a big step forward in our understanding of cell reprogramming. We have proved that cells can be rejuvenated without losing their function and that rejuvenation looks to restore some function to old cells.” A stem cell biologist and co-founder of the skincare company Heraux, Ben Van Handel told <a href="https://www.livescience.com/skin-cell-rejuvenation-30-years-younger">Live Science</a>, “technique will never be used in a clinical setting as it is currently a type of gene therapy that would be impossible to use in humans." According to him, there is still a lot of concern about these cells becoming cancerous and controlling how far back in age the rejuvenation process goes.” SEE ALSO: <a href="https://www.businessinsider.in/tech/news/mark-zuckerbergs-metaverse-obsession-is-driving-some-current-and-former-facebook-employees-nuts-its-the-only-thing-mark-wants-to-talk-about/articleshow/91001496.cms">Mark Zuckerberg's metaverse obsession is driving some current and former Facebook employees nuts: 'It's the only thing Mark wants to talk about'</a> <a href="https://www.businessinsider.in/tech/news/barack-obama-said-social-media-is-turbocharging-some-of-humanitys-worst-impulses-and-called-for-reform-to-section-230/articleshow/91001492.cms">Barack Obama said social media is 'turbocharging some of humanity's worst impulses' and called for reform to Section 230</a>

Researchers have discovered a de-ageing technique that made skin cells 30 years younger

<ul><li>Scientists have reversed the effects of ageing by putting young mouse poop in old mice.</li><li>The experiment reversed the key signs of ageing in the guts, eyes, and brains of older mice.</li><li>Earlier, Indian-origin doctor, Diljeet Gill used a new technique to make skin cells younger.</li></ul>The scientists from <keyword id="8171224" type="General" weightage="50" keywordseo="quadram-institute" source="Orion">Quadram Institute</keyword> have provided evidence from research, that transplanting faecal microbiota from young to old mice can reverse ageing signs in the eyes, gut, and brain of older mice. Professor Simon Carding, Head of the Gut Microbes and Health Research Programme said, “this groundbreaking study provides tantalizing evidence for the direct involvement of gut microbes in ageing and the functional decline of brain function and vision and offers a potential solution in the form of gut microbe replacement therapy.” According to these new findings we can assume, that gut microbes play a critical role in regulating ageing effects and open different pathways to explore gut microbe potential in anti-ageing therapies. The research is published in the journal <a href="https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-022-01243-w#author-information">Microbiome</a>. Further, research showed, that moving gut microbes from the poop of aged mice into younger mice showed the signs of ageing including inflammation and disturbed vision. It also showed a loss of integrity in the gut lining which can pass bacteria into the bloodstream. Age-related chronic inflammation- inflammaging were also activated in younger mice. The team is also working to understand how long positive effects can last and how components of the younger donor microbiota can impact organs distant from the gut. In addition, to facilitate such research, a new facility for <keyword id="13840553" type="General" weightage="20" keywordseo="Microbiota-Replacement-Therapy" source="Orion">Microbiota Replacement Therapy</keyword> is being built in the Quadram Institue. Dr <keyword id="13840552" type="General" weightage="80" keywordseo="aimee-parker" source="Orion">Aimee Parker</keyword>, the lead author of the study said “we were excited to find that by changing the gut microbiota of elderly individuals, we could rescue indicators of age-associated decline commonly seen in degenerative conditions of the eye and brain. Our results provide more evidence of the important links between microbes in the gut and the healthy ageing of tissues and organs around the body. We hope that our findings will contribute ultimately to understanding how we can manipulate our diet and our gut bacteria to maximize good health in later life.” Earlier, Indian-origin doctor, Diljeet Gill a postdoctoral candidate at the Babraham Institute in Cambridge used a new <a href="https://www.businessinsider.in/tech/news/researchers-have-discovered-a-de-ageing-technique-that-made-skin-cells-30-years-younger/articleshow/91004651.cms">technique to make skin cells younger</a>. The research included ‘maturation phase transient reprogramming’ to fibroblasts which is a common type of skin cell. The team took skin cells from middle-aged donors and once the research was completed, older skin cells were compared to younger skin cells from donors aged 20 to 22. They found skin cells were similar to younger cells, genetically and chemically. SEE ALSO: <a href="https://www.businessinsider.in/tech/news/useful-imessage-tips-and-tricks-to-master-texting-on-iphone-and-ipad/articleshow/91365622.cms">Useful iMessage tips and tricks to master texting on iPhone and iPad</a> <a href="https://www.businessinsider.in/tech/news/bigwigs-at-chinas-uber-didi-and-lenovo-have-retreated-from-the-social-media-platform-weibo-joining-other-chinese-tech-moguls-who-are-hiding-from-public-view/articleshow/91366174.cms">Bigwigs at 'China's Uber' Didi and Lenovo have retreated from the social media platform Weibo, joining other Chinese tech moguls who are hiding from public view</a>

Scientists may have found a crappy way to reverse the effects of ageing

<ul class="summary-list"><li>Babraham Institute in Cambridge announced on Thursday researchers had successfully rejuvenated <keyword id="11899253" type="UNKNOWN" weightage="60" keywordseo="skin" source="Orion">skin</keyword> cells.</li><li>Scientists reprogrammed adult skin cells to look and behave 30 years younger than the original.</li></ul>A team in the Babraham Institute in Cambridge has successfully rejuvenated a 53-year-old woman's skin cells to look and behave like a 23-year-old's, the research center <a href="https://www.babraham.ac.uk/news/2022/04/new-technique-rewinds-age-skin-cells-30-years">announced</a> on Thursday.The team had initially set out to create <a href="https://www.businessinsider.com/embryonic-stem-cells-lead-to-human-cloning-2013-5">embryonic stem cells</a>, which can divide into any type of cell in the body, using adult cells. Nobel Award winner <a href="https://www.nobelprize.org/prizes/medicine/2012/press-release/">Shinya Yamanaka</a>, a researcher at Kyoto University in Japan, first turned "normal" cells that have a specific function into <keyword id="12394098" type="UNKNOWN" weightage="60" keywordseo="stem-cells" source="Orion">stem cells</keyword> back in 2006. <a href="https://www.bbc.com/news/science-environment-60991675">The BBC reported</a> German molecular biologist Wolf Reik, postdoctoral student Diljeet Gill, and a team at Babraham Institute built upon Yamanaka's work. Yamanaka grew stem cells by exposing adult cells to four molecules for about 50 days — a unique method he named <a href="https://www.nature.com/articles/534310a">iPS.</a> Reik and Gill's team exposed skin cells to the same molecules for only 13 days, then let them grow under natural conditions.By <a href="https://www.eurekalert.org/news-releases/948982">studying collagen production in the cells</a>, the researchers found age-related changes on skin cells were removed and they temporarily lost their identity. After growing under normal conditions for a period of time, researchers found the cells began behaving like skin cells again.The team then measured age-related biological changes in the reprogrammed cells, and found the cells matched the profile of those 30 years younger to reference data sets, Gill said in a <a href="https://www.babraham.ac.uk/news/2022/04/new-technique-rewinds-age-skin-cells-30-years">release</a>."I remember the day I got the results back and I didn't quite believe that some of the cells were 30 years younger than they were supposed to be," Gill told BBC. "It was a very exciting day."The research was done in a lab, and Reik told the BBC the team cannot take the technique to a clinic because the technique used to rejuvenate the cells has the potential to <a href="https://jeccr.biomedcentral.com/articles/10.1186/s13046-020-01584-0">increase the risk of cancer, </a>likely due to creating <a href="https://www.eurostemcell.org/ips-cells-and-reprogramming-turn-any-cell-body-stem-cell">lasting genetic changes within cells</a>.But the biologist said the method of rejuvenating cells could help speed up healing time in burn victims, and may eventually extend human life. "Eventually, we may be able to identify genes that rejuvenate without reprogramming, and specifically target those to reduce the effects of aging," Reik said in a <a href="https://www.babraham.ac.uk/news/2022/04/new-technique-rewinds-age-skin-cells-30-years">press release</a>.The researchers published their findings in the journal <a href="https://elifesciences.org/articles/71624" target="_blank" rel="noopener">eLife</a> on April 8.

Scientists rejuvenated the skin of a 53-year-old woman to that of a 23-year-old's in a groundbreaking experiment

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Researchers have discovered a de-ageing technique that made skin cells 30 years younger

Rahul Verma

Scientists may have found a crappy way to reverse the effects of ageing

Rahul Verma

Scientists rejuvenated the skin of a 53-year-old woman to that of a 23-year-old's in a groundbreaking experiment

Allana Akhtar

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