<p><div class="KonaFilter image-container display-table float_right"><div><div class="image on-image"><p class="source"><span>Lisa Lake/Getty</span></p><p class="caption">Axovant founder Vivek Ramaswamy</p></div><p></p></div></div>Axovant, a company <a href="http://www.businessinsider.com/axovant-alzheimers-drug-starts-phase-3-trial-2015-10">founded by 32-year-old</a> Vivek Ramaswamy, just failed a key late-stage trial for its Alzheimer's drug.</p><p>Axovant is the latest in a series of failures to get an Alzheimer's drug approved. 99% of all Alzheimer's drugs have failed clinical trials in the past decade.</p><p>There are only four approved drugs that treat the symptoms of the disease, which affects <a href="http://www.alz.org/facts/">more than 5 million Americans</a>.</p><p>The most recent drug approval happened in 2003. </p><p>"While we are deeply disappointed by these trial results, we also are saddened for the millions of patients and families impacted by Alzheimer's disease," Axovant CEO David Hung said. "However, we believe that the fight against Alzheimer's and other important areas of unmet need in neurology is too important to be derailed by this setback."</p><p><span>T</span><span>he hope for the drug, called intepirdine, was to combine it with donepezil, an Alzheimer's drug currently in use. Taken together, the two seemed to slow the loss of cognition and ability to perform daily tasks more effectively than when donepezil was taken alone. </span> </p><h2><strong>Why it might not have been the 'breakthrough' people are looking for</strong></h2><p>The goal of the drug was to treat the symptoms associated with the disease, such as cognition and behavior changes. intepirdine, as far as researchers know, can't reverse the effects of Alzheimer's or cure the disease. More realistically, Axovant CEO David Hung said in August he was hopeful they might find a disease-modifying effect, which<span>  </span><a href="http://www.businessinsider.com/what-an-alzheimers-cure-might-look-like-2016-8">could</a><span><a href="http://www.businessinsider.com/what-an-alzheimers-cure-might-look-like-2016-8">  push back</a> the timeline on the disease</span>. </p><p>Axovant wasn't the only drug that's taken this approach: In February,<span> </span><a href="http://www.businessinsider.com/r-lundbeck-gives-up-on-alzheimers-drug-rival-to-axovant-pill-2017-2">Danish drugmaker Lundbeck</a><span> </span>said two of its trials on the company's 5HT6 antagonist had failed. In 2016,<span> </span><a href="http://www.businessinsider.com/axovant-shares-tumble-after-rival-drug-fails-2016-2">Pfizer shut down</a><span> </span>its trials on a drug that acted on the 5HT6 receptor as well. </p><p>Even though intepirdine failed, Hung still has big plans for Axovant. </p><p>The company's also looking at how intepirdine works in people who have Lewy Body Dementia, a <a href="http://www.businessinsider.com/neurological-disorders-drug-development-challenges-2016-12">neurodegenerative</a> disease with symptoms that look like Alzheimer's or Parkinson's. In that trial, people received a higher dose of intepirdine. It's expected to have results by the end of the year. Axovant also has three other drugs, which are earlier in development.</p>    <div class="margin-top">        <h3>NOW WATCH: <a href="http://www.businessinsider.com/akamai-analyst-scott-kessler-favorite-tech-stock-2017-9">A top analyst explains why his favorite tech stock is one of the worst performers of the year</a></h3>        <div>                    </div>    </div>

A biotech founded by a 32-year-old just failed a key Alzheimer's drug trial

<p><div class="KonaFilter image-container display-table"><div><div class="image on-image"><p class="source"><span>AP Photo, File</span></p><p class="caption">Boston Red Sox first baseman Bill Buckner.</p></div><p></p></div></div></p><ul class="summary-list"><li><strong>Bill Buckner, a star hitter who became known for making one of the most infamous plays in major league history has died at the age of 69.</strong></li><li><strong>Buckner became famous for a hit up the first base line that rolled through his legs, an error that allowed the winning run for the Mets in the 1986 World Series. </strong></li><li><strong>His last major public appearance was in 2008, when he accepted an invitation to throw out the first ball for the home opener at Fenway Park as the Red Sox celebrated winning another title.</strong></li><li><strong><a href="https://www.businessinsider.com/?hprecirc-bullet">Visit Business Insider's homepage for more stories</a></strong></li></ul><p>BOSTON (AP) - Bill Buckner, a star hitter who became known for making one of the most infamous plays in major league history, died Monday. He was 69.</p><p>He died after a long battle with Lewy body dementia, Buckner's family said in a statement. The disease causes Alzheimer's-like symptoms along with movement and other problems.</p><p>"Bill fought with courage and grit as he did all things in life," his family said.</p><p>Buckner won an NL batting title, was an All-Star and got 2,715 hits in a 22-year career. He was long considered a gritty player, a gamer who would be welcome on any team. A reliable fielder, too.</p><p>But it was a little groundball in the 1986 World Series that forever changed his legacy.</p><p>Trying for their first crown since 1918, the Boston Red Sox led the New York Mets 5-3 going into the bottom of the 10th inning in Game 6 at Shea Stadium. The Mets tied it with two outs, then Mookie Wilson hit a trickler up the first base line that rolled through Buckner's legs, an error that let Ray Knight rush home from second base with the winning run.</p><p><div class="KonaFilter image-container display-table"><div><div class="image on-image"><p class="source"><span><a href="https://newsroom.ap.org/detail/BillBucknerforeverknownforOctobererrordiesat69/19b4a10978aa49a39928ec31b559075f/text?Query=buckner&amp;mediaType=text&amp;sortBy=arrivaldatetime:desc&amp;dateRange=Anytime&amp;totalCount=4&amp;currentItemNo=2">Stan Grossfeld/The Boston Globe via AP, File</a></span></p><p class="caption">In this Oct. 25, 1986, file photo, Boston Red Sox first baseman Bill Buckner misplays the ball during during Game 6 of the World Series against the New York Mets.</p></div><p></p></div></div></p><p>The Red Sox lost 8-5 in Game 7, and their World Series drought continued until they won the championship in 2004.</p><p>In the aftermath of Boston's near-miss, Buckner became a target of fans in New England and beyond, with his misplay shown over and over on highlight reels.</p><p>Buckner was released by the Red Sox the following summer, went on to play for the Angels and Royals, and returned to Boston for his final season in 1990, playing 22 games.</p><p>In 2008, Buckner accepted an invitation to throw out the first ball for the home opener at Fenway Park as the Red Sox celebrated winning another title.</p><p>Buckner drew loud cheers as he walked from the Green Monster in left field to the mound, and made his ceremonial toss to former teammate Dwight Evans.</p><p>Buckner said the moment was "probably about as emotional as it could get."</p><p>"I really had to forgive," he said later that day, "not the fans of Boston per se, but I would have to say, in my heart, I had to forgive the media for what they put me and my family through. So I've done that. I'm over that. And I'm just happy that I just try to think of the positive. The happy things."</p><p>"You can look at that Series and point fingers in a whole bunch of different directions," Buckner said. "We did the best we could to win there and it just didn't happen and I didn't feel like I deserved" so much blame.</p><p><div class="KonaFilter image-container display-table float_right"><div><div class="image on-image"><p class="source"><span>AP Photo/Charles Krupa, File</span></p><p class="caption">In this May 25, 2016, file photo, former Boston Red Sox player Bill Buckner looks on prior to a baseball game against the Colorado Rockies in Boston.</p></div><p></p></div></div></p><p>Cleveland manager Terry Francona was the Red Sox skipper that afternoon at Fenway. On Monday, with the Indians set to play in Boston, Francona reflected on that experience.</p><p>"I thought it was kind of a healing moment, it seemed, for a lot of people and for him, I hope," Francona said. "You have to be up here to understand how people take things that happen. I thought that was a really cool moment."</p><p>Buckner lived in Boise, Idaho, after he finished playing. He was the hitting coach for the Chicago Cubs' minor league affiliate in Boise in 2012-13, owned three car dealerships and several commercial properties in Idaho.</p><p>Cubs chairman Tom Ricketts called Buckner a "great ballplayer and beloved member of the Cubs family."</p><p>Buckner also became friendly with Wilson, who hit that grounder. While Buckner was long criticized for the error, many in baseball contend that even if the ball had been handled cleanly, the speedy Wilson would have beaten it anyway.</p><p>Buckner made his big league debut with the Dodgers at 19 in 1969, was a batting champ with the Cubs and played until he was 40. He had a career .289 average and over 100 RBIs in three seasons, twice with Boston. Buckner finished with 174 home runs and 1,208 RBIs.</p><p>He is survived by his wife, Jody, two daughters and one son.<br />___<br />More AP MLB: https://apnews.com/MLB and https://twitter.com/AP_Sports</p>    <div class="margin-top">        <h3>NOW WATCH: <a href="https://www.businessinsider.com/game-of-thrones-series-finale-22-details-you-missed-2019-5">22 details in the 'Game of Thrones' finale you might have missed</a></h3>        <div>                    </div>    </div>

Red Sox legend Bill Buckner, known for 1986 World Series play, has died at 69

<p><div class="KonaFilter image-container display-table click-to-enlarge"><div><div class="image"><a title_source="Carlo Allegri/Getty Images" title_caption="" class="zoomin" href="https://static-ssl.businessinsider.com/image/539de30b69bedde728176a9f-960/casey-kasem-2.jpg"><span class="sprites click-to-enlarge-icon" title="Click to enlarge"></span></a><p class="source"><span>Carlo Allegri/Getty Images</span></p></div><p></p></div></div>Legendary radio voice Casey Kasem passed away early Sunday at the age of 82.</p>
<p>Kasem's daughter, Kerri, shared the news Sunday in a <a href="https://www.facebook.com/pages/Kerri-Kasem/142845292421119" target="_blank">Facebook posting</a>.</p>
<p><div class="KonaFilter image-container display-table"><div><div class="image"><p class="source"><span><a href="https://www.facebook.com/pages/Kerri-Kasem/142845292421119">Kerri Kasem/Facebook</a></span></p></div><p></p></div></div></p>
<p>According to a statement from Kasem's PR, the disc jockey passed away at 3:23 a.m.</p>
<p>For the past two weeks, Kasem was hospitalized at St. Anthony's Hospital in Gig Harbor, Washington following <a href="http://www.businessinsider.com/casey-kasem-found-in-washington-2014-5" target="_blank">a family feud</a> between Kasem's wife, Jean, and three children from his first marriage.</p>
<p>According to Kasem's children, Kasem suffered from <a href="http://www.nbcnews.com/health/health-news/casey-kasems-little-known-dementia-heartbreaking-docs-say-n104576" target="_blank">Lewy body disease</a>, a form of dementia.</p>
<p><span>For more than four decades, Kasem lent his voice talents to the radio hosting music countdown shows.</span></p>
<p><span>His most popular show, "American Top 40," has been around since 1970. Ryan Seacrest took over hosting duties in 2004.</span></p>
<p>Kasem also <a href="http://www.businessinsider.com/casey-kasem-burger-king-commercial-2014-6" target="_blank">provided the voice for Shaggy</a> in the "Scooby-Doo, Where Are You!" cartoons.</p>
<p><span>A memorial service will be held Friday.</span> </p>
<p>In his memory, here's a clip of Kasem opening the "American Top 40" in 1970:</p>
<p></p>

You Searched For "Lewy Body Dementia" and got 3 results

A biotech founded by a 32-year-old just failed a key Alzheimer's drug trial

Lydia Ramsey

Red Sox legend Bill Buckner, known for 1986 World Series play, has died at 69

Ellen Cranley,Ellen Cranley

Legendary Radio Icon Casey Kasem Dies At 82

Kirsten Acuna