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<ul><li>Confirmed cases of COVID-19 infection cross 12 lakhs around the globe with the number of deaths reported nearing 70,000. </li><li>The malignant virus invades more than 200 countries and the demand for drugs and medical equipment surge fast. </li><li>The anti-malarial drug <keyword id="4751090" type="PERSON" weightage="20" keywordseo="Hydroxychloroquine">Hydroxychloroquine</keyword> is seen as a game changer in treating COVID-19 infection. Here are the basics of this life-saving drug you must know.</li></ul>In a recent conversation with the Prime Minister of India, Donald Trump, the American President requested India to supply them huge quantities of Hydroxychloroquine. Addressing the press, Trump also warned of retaliation measures if India declined the request as it did to other countries in the face of perceiving a demand for the drug with the cases mounting up in the country too. What is <keyword id="8947192" type="UNKNOWN" weightage="20" keywordseo="Hydroxychloroquine-medicine">Hydroxychloroquine medicine</keyword> Hydroxychloroquine can be described as a racemic mixture comprising of R and S enantiomer. We can compare Hydroxychloroquine with chloroquine, an aminoquinoline. This is a commonly prescribed medicine in treating uncomplicated malaria, rheumatoid arthritis, systemic lupus erythematosus, and chronic discoid lupus erythematosus. Hydroxychloroquine is also used to address the prophylaxis of malaria in places where chloroquine resistance is unlikely. Developed during World War II as a derivative of quinacrine, this drug is said to have much lesser side effects. The FDA approved this drug on 18 April 1955. In the face of COVID-19 pandemic, the FDA has sanctioned an emergency authorization for hydroxychloroquine and chloroquine. This authorization gives room for the unapproved use of these drugs in treating the COVID-19 cases in the light of the critical public emergency seen around. The effectiveness of hydroxychloroquine in remedying the COVID-19 infection is yet to be proved though this drug is administered in the treatment in a large scale as on date. The American experiment Towards the end of March 2020, the US Food and Drug Administration provisionally approved the use of hydroxychloroquine in treating COVID-19 patients. Since then, the medical community in New York has been administering this drug to the novel coronavirus infected patients in combination with some other drugs. This experiment with hydroxychloroquine happening in the epicenter of the US has given a hint to Trump, the American President that this anti-malarial drug could be a game changer in treating COVID-19 infection. He said that this drug was giving successful results and if the trend continued, it would be a gift from heaven. The country had then quickly stocked up about 29 million doses of hydroxychloroquine besides asking India to supply the drug to them. India’s policy on hydroxychloroquine supplies to the world Last month, India had imposed a ban on the export of hydroxychloroquine. However, India is most likely to life the ban and clear the pending international orders for the drug after meeting the local requirements. It is also said that after perceiving the humanitarian situation of the COVID-19 scenario, the Department of Pharmaceuticals and Ministry of External Affairs will decide whether to fulfill the pending international orders for hydroxychloroquine. See Also - <a href="https://www.businessinsider.in/india/news/india-lifts-partial-ban-on-hydroxychloroquine-after-donald-trump-warns-of-retaliation-if-pm-modi-doesnt-help-the-us/articleshow/75022401.cms">India lifts partial ban on hydroxychloroquine medicine</a>

What is Hydroxychloroquine medicine and how it could be a game changer

New York, Apr 26 () Patients with COVID-19 who were on a regimen of the drugs hydroxychloroquine and azithromycin experienced cardiac abnormalities, according to a study which recommends the continuous monitoring of heart beat rhythms in infected people with underlying health conditions. The research, published in the journal Nature Medicine, assessed 84 patients with COVID-19 treated at a centre in New York in the US. Recent reports have suggested that the combination of the anti-malaria drug hydroxychloroquine, and the antibiotic azithromycin may help patients with COVID-19, said scientists from the New York University School of Medicine in the US. However, they said both medications may increase the risk of various types of cardiac rhythm abnormalities, such as sudden cardiac death, QTc-interval prolongation, and drug-induced torsades de pointes. The researchers explained that the QTc interval is measured by an electrocardiogram, and represents the time it takes for a heart to recharge between beats. A prolonged QTc interval puts a patient at risk for irregular heart beats, also called arrhythmia, and sudden cardiac death, they said. The scientists, including Lior Jankelson, reviewed the charts and followed the QTc interval of 84 patients with COVID-19 on a 5-day oral regiment of hydroxychloroquine and azithromycin. They said the patients were, on average, 63 years of age and 74 per cent of them were male. After the patients were administered the drugs, the scientists followed up with an electrocardiogram -- a test that measures the electrical activity of the heart to shed light on its functioning. In most patients, they observed a prolonged QTc, which was severely prolonged in 11 of the them. According to the researchers, this put the patients at high risk of irregular heart beats and sudden cardiac death. The study noted that four patients in the cohort died from multiple organ failure, without evidence of arrhythmia, and without severe QTc prolongation. Jankelson and his colleagues also found that most patients with COVID-19 who were treated with hydroxychloroquine and azithromycin experienced QTc prolongation. They said this may have been exacerbated by other pre-existing conditions and the severity of the SARS-CoV-2 infection. According to the scientists, the QTc in patients with COVID-19 who are treated with hydroxychloroquine and azithromycin should be monitored constantly, especially for patients with additional illnesses and those who are being treated with other QT-prolonging medications. VIS VISVIS

Cardiac abnormalities in COVID-19 patients treated with hydroxychloroquine: Study

Oxford, Jun 16 (AP) Researchers in England say they have the first evidence that a drug can improve COVID-19 survival: A steroid called dexamethasone reduced deaths by up to one third in severely ill hospitalized patients. Results were announced Tuesday and researchers said they would publish them soon. The study is a large, strict test that randomly assigned 2,104 patients to get the drug and compared them with 4,321 patients getting only usual care. The drug was given either orally or through an IV. It reduced deaths by 35% in patients who needed treatment with breathing machines and by 20% in those only needing supplemental oxygen. It did not appear to help less ill patients. "This is an extremely welcome result," one study leader, Peter Horby of the University of Oxford, said in a statement. "The survival benefit is clear and large in those patients who are sick enough to require oxygen treatment, so dexamethasone should now become standard of care in these patients. Dexamethasone is inexpensive, on the shelf, and can be used immediately to save lives worldwide." This is the same study that earlier this month showed the malaria drug hydroxychloroquine was not working against the coronavirus. The study enrolled more than 11,000 patients in England, Scotland, Wales and Northern Ireland who were given either standard of care or that plus one of several treatments: the HIV combo drug lopinavir-ritonavir, the antibiotic azithromycin; the steroid dexamethasone, the anti-inflammatory drug tocilizumab, or plasma from people who have recovered from COVID-19 that contains antibodies to fight the virus. Research is continuing on the other treatments. The research is funded by government health agencies in the United Kingdom and private donors including the Bill and Melinda Gates Foundation. (AP) PMS PMS PMS

First drug proves able to improve survival from COVID-19

<ul class="summary-list"><li>Aaron Rodgers lost an appeal to the NFL to have an alternative COVID-19 treatment count as being vaccinated.</li><li>Rodgers said on "The Joe Rogan Experience" that during his appeal with the NFL, he was called a "conspiracy theorist."</li></ul>NFL quarterback Aaron Rodgers told Joe Rogan that he was called a "conspiracy theorist" while appealing to the NFL to count an alternative COVID-19 treatment as being fully vaccinated.<a href="https://open.spotify.com/show/4rOoJ6Egrf8K2IrywzwOMk">Speaking on "The Joe Rogan Experience,"</a> Rodgers described an alternative treatment he received last summer, in which he claims he took a "diluted strand" of the virus orally for several months.While arguing with the NFL over the reliability and protection this treatment would provide against COVID, Rodgers said someone responded by calling him a conspiracy theorist.Rodgers did not specify who made the comment, referring only to the person as "he."The NFL did not respond to Insider's request for comment.Rodgers had previously described this meeting during a <a href="https://www.youtube.com/watch?v=Y3JU_oAEinQ&amp;t=4723s">November 5 interview on "The Pat McAfee Show."</a> Rodgers said he knew his appeal wasn't going to get approved when "one of the main" doctors in the meeting responded that vaccinated people couldn't contract or transmit the virus.However, last November, the NFL said Rodgers hadn't spoken directly with any of its medical experts during the appeal process.<a href="https://apnews.com/article/coronavirus-pandemic-nfl-sports-health-immunizations-9484a87691720061a5cb2258a9c26078">Barry Wilner of The Associated Press reported</a>, on November 6, 2021, that the Packers had emailed the NFL Players Association's medical director, Dr. Thom Mayer, to see if a homeopathic treatment would count as being fully vaccinated. Dr. Mayer shared the email and "related materials" from Rodgers with Dr. Allen Sills, the league's medical chief, and with an independent infectious disease expert.According to Wilner, the expert said there was a lack of scientific data that showed Rodgers' treatment plan could offer protection against COVID-19.Rodgers has not received a COVID-19 vaccine. He told Rogan that he is allergic to Polyethylene Glycol (PEG), an ingredient in the mRNA COVID-19 vaccines. He did not take the Johnson &amp; Johnson vaccine after it had been paused because of blood-clotting issues in some recipients.Rodgers said he knew "hundreds, if not thousands" of people who had received the same treatment he did."So that was my only option – do nothing or do this process," he told Rogan. "And I felt like this was the best way to protect myself and my teammates and that the NFL would understand and maybe grant me a waiver."<div type="image" title="Side-by-side screenshots show Joe Rogan speaking into a mic and Aaron Rodgers speaking into a mic during a podcast." height="1000" width="2000" msid="93886934" hostid="261" sizebytes="55858"></div>Rodgers caught COVID in November. Despite previously telling reporters he had been immunized, it became apparent he had not received a vaccine, based on the NFL protocols he had to enter for his positive test.On the podcast, <a href="https://www.insider.com/aaron-rodgers-thanks-joe-rogan-covid-treatment-game-plan-2022-8">Rodgers thanked Rogan</a> for giving him a treatment "game plan" when he got COVID. <a href="https://www.insider.com/aaron-rodgers-covid-19-ivermectin-hydroxychloroquine-2021-11">Rodgers had previously told "The Pat McAfee Show"</a> that he took Ivermectin, hydroxychloroquine, and different vitamins.Though ivermectin — an antiparasitic drug — and hydroxychloroquine — typically used to treat malaria — have both been promoted as COVID-19 treatments by vaccine skeptics, public health authorities <a href="https://www.reuters.com/article/factcheck-hydroxychloroquine-covid-guida/fact-check-u-s-government-guidance-against-use-of-hydroxychloroquine-for-treating-covid-19-has-not-changed-in-2021-idUSL1N2M70NL">have</a> <a href="https://www.businessinsider.com/why-ivermectin-being-used-treat-covid-2-doctors-leading-charge-2021-9">not</a> approved the drugs as effective or safe treatments for the virus.Rogan previously came under fire for saying that young people do not need to get a COVID vaccine. He <a href="https://www.insider.com/joe-rogan-walks-back-vaccine-comments-2021-4">responded to the backlash</a> by saying: "I'm not a doctor. I'm a fucking moron. I'm not a respected source of information, even for me."

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What is Hydroxychloroquine medicine and how it could be a game changer

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Cardiac abnormalities in COVID-19 patients treated with hydroxychloroquine: Study

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First drug proves able to improve survival from COVID-19

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Aaron Rodgers says he was called a conspiracy theorist during his appeal to the NFL for an alternative COVID treatment

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2 fringe doctors created the myth that ivermectin is a 'miracle cure' for COVID-19 - whipping up false hope that could have deadly consequences

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