<p></p><p>It was somewhat surprising - among the sodas, and cars, and big name consumer goods brands - to see an ad about constipation airing during the Super Bowl this year.</p><p>But, yes, it did actually happen.</p><p>The ad, promoting a prescription product to help tackle opioid-induced constipation (OIC) was courtesy of Astra Zeneca.</p><p>OIC is no laughing matter and the ad was clearly designed to raise awareness about the affliction amongst the audience of more than 100 million people watching the game.&#xa0;</p><p>But those good intentions&#xa0;didn't stop the memes and mockery emerging on Twitter almost immediately after the ad aired:</p><p><div></div></p><p class="embed-spacer"><div></div></p><p class="embed-spacer">&#xa0;<div></div></p><p class="embed-spacer">&#xa0;<div></div></p><p class="embed-spacer">&#xa0;<div></div></p><p><div></div></p><p class="embed-spacer">&#xa0;<div></div></p><p><div></div></p>    <div class="margin-top">        <h3>NOW WATCH: <a href="http://www.businessinsider.com/mountain-dew-super-bowl-ad-puppymonkeybaby-2016-2">PuppyMonkeyBaby: This Super Bowl ad is incredibly polarizing</a></h3>        <div>            <div>        <div class="ooyala-video-player" data-video-autoplay="false" data-video-id="wydWpuMDE6EgO2rK3oC9inpOMKJeeQVp" data-player-variable="ooyalapopvideo" id="ooyalaplayer_popvideo" style="width:1280px;height:720px"></div>        </div>        </div>            </div>

Everyone is talking about the weird constipation ad that aired during the Super Bowl

<p><div class="KonaFilter image-container display-table"><div><div class="image"><p class="source"><span>REUTERS/Lucas Jackson</span></p><p class="caption">Workers raise a U.S. flag outside the Pfizer building in New York.</p></div><p></p></div></div>Earlier today, pharmaceutical giant <a href="http://www.businessinsider.com/pfizer-astrazeneca-2014-4">Pfizer confirmed</a> that it made peer AstraZeneca a merger proposal in a deal valued at $100 billion.</p>
<p>In a note to clients last week, Morgan Stanley's David Risinger addressed the deal rumor and explained why Pfizer would want to pursue it.</p>
<p style="padding-left: 30px;"><strong>Strategic rationale. Astra Zeneca would dramatically boost Pfizer's presence in primary care (incl. respiratory and diabetes), oncology (in particular immuno-oncology candidates), and Emerging Markets, among other areas. It would also offer significant cost rationalization opportunities-Pfizer mgmt has a track record of delivering above-forecast merger cost savings. However, size works against R&amp;D productivity because large entities often stifle innovation.</strong></p>
<p>As with any merger, this deal would certainly increase the combined company's geographic footprint and addressable market. Also, you're looking at cost-synergies (e.g. layoffs, combined offices).</p>
<p>But that last point on R&amp;D is a bit depressing. The combined company would likely become one who's R&amp;D department would lurch unlike the ones belonging to the smaller nimble companies whose lives depending on the success of what's coming out of the R&amp;D pipeline.</p>
<p>Interestingly, becoming bigger goes against a strategic shift Pfizer had been pursuing for years.</p>
<p>"Pfizer mgmt has been seeking to downsize in order to grow faster off a smaller base later this decade," noted Risinger. "Pfizer recently exited its Nutritional and Animal Health (Zoetis) businesses, and mgmt has stated publicly that it could consider exiting certain Established Products (off-patent drugs)."</p>

In One Paragraph, Here's Why A Pfizer Wants To Buy AstraZeneca

<p><div class="KonaFilter image-container display-table float_right"><div><div class="image on-image"></div><p></p></div></div>Good morning! Here's everything you need to know in the world of <keyword id="35666" type="COMPANY" weightage="100" keywordseo="advertising">advertising</keyword> today.</p><p><strong>1. <a href="http://www.businessinsider.com/tinder-to-roll-out-video-for-users-2015-6">Tinder is about to launch a video dating feature.</a> </strong>Tinder users have really engaged with video advertising on the app, co-founder Sean Rad says, which has prompted the company to consider letting users add video to their profiles.</p><p><strong>2. <a href="http://www.businessinsider.com/sheryl-sandberg-and-lean-in-organized-cannes-glass-lion-2015-6">Facebook COO Sheryl Sandberg is launching a brand new award at Cannes Lions International Festival of Creativity to help shatter gender stereotypes.</a> </strong>The Glass Lion award will recognize ads that explores ideas of gender and specifically address issues of gender inequality or prejudice. </p><p><strong style="line-height: 1.5em;">3. <a href="http://www.businessinsider.com/facebook-still-cool-teenagers-instagram-2015-6">Teenagers still think Facebook is cool.</a> </strong>Facebook's vice president of Europe, the Middle East, and Africa Nicola Mendelson says she has a "sneaky" focus group - her own children - which shows that teenagers still spend plenty of time on the site.<strong style="line-height: 1.5em;"><a href="http://www.businessinsider.com/mcdonalds-shrinks-in-us-while-expanding-overseas-2015-6"><br /></a></strong></p><p><strong>4. <a href="http://www.adweek.com/news/advertising-branding/two-talking-dead-fish-won-top-pharma-advertising-prize-cannes-165481">Digital LBi came top in the Pharma category of the Cannes Lions festival this weekend, marking the first Grand Prix from a US company this year.</a> </strong>Adweek reports that the company won for an Astra Zeneca campaign featuring two dead fish educating men about heart health.<strong><a href="http://www.undertone.com/2015/06/undertone-sparkflow"><br /></a></strong></p><p><strong>5. <a href="http://www.businessinsider.com/mcdonalds-invents-bike-friendly-takeout-bag-2015-6">McDonalds has designed a new takeout bag that fits on a bicycle's handlebars.</a> </strong>The McBike bag was designed by ad agency Tribal Buenos Aires in Argentina, and debuted in Copenhagen. </p><p><strong style="line-height: 1.5em;">6. <a href="http://blogs.wsj.com/cmo/2015/06/22/facebook-outlines-new-ad-formats-for-mobile/">Facebook is expected to outline a new format for mobile advertising at Cannes</a>.<a href="http://blogs.wsj.com/cmo/2015/06/22/facebook-outlines-new-ad-formats-for-mobile/"> </a></strong>According to WSJ's CMO Today, advertisers may be able to add full-screen video, product information, and other content to their own branded, interactive destinations on Facebook. </p><p><strong>7. <a href="http://blogs.wsj.com/cmo/2015/06/22/magna-global-cuts-global-advertising-growth-forecast-as-emerging-markets-slow/">Magna Global just reduced its global advertising revenue forecast for the year to $513 billion, a growth of 3.9% from 2014 spending levels.</a> </strong>CMO Today reports that worldwide ad revenue is unlikely to see the same 4.9% boost as last year because growth from emerging markets is slowing.<strong><a href="http://www.businessinsider.com/apple-patent-for-viral-advertising-in-social-media-2015-6"><br /></a></strong></p><p><strong>8.<a href="http://www.adweek.com/news/advertising-branding/180la-tries-recruit-new-creative-director-sneaky-award-entry-cannes-165480"> Advertising agency 180LA submitted a sneaky recruitment ad for a new CMO as an award entry in four Cannes competitions.</a> </strong>Adweek reports that the video is a mock case study explaining the kind of personal "results" a creative director can achieve by joining the company.<strong><a href="http://www.businessinsider.com/different-facebook-uses-in-africa-and-the-middle-east-nicola-mendelsohn-2015-6"><br /></a></strong></p><p><strong>9. <a href="http://www.businessinsider.com/wimbledon-lawn-tennis-club-digital-boss-on-periscope-2015-6">Wimbledon spectators will be heavily discouraged from using streaming apps like Periscope during this summer's tournament</a>.<a href="http://www.businessinsider.com/wimbledon-lawn-tennis-club-digital-boss-on-periscope-2015-6"> </a></strong>But Wimbledon's digital team will use the app themselves to capture specific moments of the tournament<strong>. <a href="http://www.businessinsider.com/how-under-armour-got-its-name-2015-6"><br /></a></strong></p><p><strong>10. <a href="http://www.businessinsider.com/amazon-will-start-paying-kindle-authors-by-the-number-of-pages-read-2015-6">Amazon is going to start paying authors by how many pages people read on their Kindle</a>. </strong>Amazon says the move comes in response to authors "who asked us to better align payout with the length of books and how much customers read."<strong><a href="http://www.businessinsider.com/twitter-wants-a-full-time-ceo-to-run-the-company-2015-6"><br /></a></strong></p>    <div class="margin-top">        <h3>NOW WATCH: <a href="http://www.businessinsider.com/wwe-brock-lesnar-facts-wrestling-2015-4">12 awesome facts about WWE superstar Brock Lesnar</a></h3>        <div>            <div>        <div class="ooyala-video-player" data-video-autoplay="false" data-video-id="c0ZDRwdDrYMxli2qszqO2efFg-yz9MeG" data-player-variable="ooyalapopvideo" id="ooyalaplayer_popvideo" style="width:1280px;height:720px"></div>        </div>        </div>            </div>

The 10 things in advertising you need to know today

<p><div class="KonaFilter image-container display-table float_right"><div><div class="image"><p class="source"><span>REUTERS/Tyrone Siu</span></p></div><p></p></div></div>Stocks were up, then down, then up again. At one point, the Nasdaq was down by as much as 1.8%. The Dow was down by 51 points.</p>
<p>First, the scoreboard:</p>
<ul>
<li><strong>Dow:</strong> 16,471.6 (+110.2, +0.6%)</li>
<li><strong>S&amp;P 500:</strong> 1,872.4 (+9.0, +0.4%)</li>
<li><strong>Nasdaq:</strong> 4,081.1, (+5.4, +0.1%)</li>
</ul>
<p>And now the top stories:</p>
<ul>
<li><span class="skimlinks-unlinked">Today's action really began when <a href="http://www.businessinsider.com/pfizer-astrazeneca-2014-4">Pfizer confirmed rumors</a> that it was making a bid for AstraZeneca in a deal worth $100 billion. Here's what Morgan Stanley's David Risinger said when it was still a rumor: "Strategic rationale. Astra Zeneca would dramatically boost Pfizer's presence in primary care (incl. respiratory and diabetes), oncology (in particular immuno-oncology candidates), and Emerging Markets, among other areas. It would also offer significant cost rationalization opportunities - Pfizer mgmt has a track record of delivering above-forecast merger cost savings. However, size works against R&amp;D productivity because large entities often stifle innovation." AstraZeneca surged 12% while Pfizer climbed 4%.<br /></span></li>
<li><span class="skimlinks-unlinked">Bank of America tumbled 6% today after management found an error in how it calculated its regulatory capital. From the <a href="http://www.businessinsider.com/bank-of-america-capital-revision-2014-4" target="_blank">BofA statement</a>: "On April 16, the company issued a press release announcing preliminary financial results for the quarter ended March 31, 2014. As part of such release, the company included estimated preliminary Basel 3 capital amounts and ratios as well as Basel 1 capital amounts and ratios for 2013. Subsequent to the press release, the company discovered an incorrect adjustment being applied in the determination of regulatory capital related to the application of the fair value option to certain legacy Merrill Lynch structured notes resulting in an overstatement of its regulatory capital amounts and ratios."<br /></span></li>
<li><span class="skimlinks-unlinked">"How can the board not come to the conclusion that Bank of America is too complex to manage?" <a href="http://www.businessinsider.com/mike-mayo-on-bank-of-america-capital-2014-4">analyst Mike Mayo said to Business Insider</a>. "I think the incident today impacts the controls, capital and credibility... I mean, banking is a business of numbers and getting the numbers right is paramount."</span></li>
<li><span class="skimlinks-unlinked"><span class="skimlinks-unlinked">The momentum stocks were once again laggards. Netflix is down 3.8%, First Solar is down 3.8%, Chipotle is down 4.3%, and Facebook is down 2.4%.</span></span></li>
<li><span class="skimlinks-unlinked"><span class="skimlinks-unlinked"><a href="http://www.businessinsider.com/march-pending-home-sales-2014-4">Pending Home sales</a> climbed 3.4% month-over-month in March, beating expectations for a 1.0% gain. Sales climbed in the Northeast, South and West but fell in the Midwest. Here's Barclays Michael Gapen on housing: " Altogether, with the exception of the very weak new home sales report for March, the bulk of housing data points to a slow recovery in the sector following the successive shocks of higher mortgage rates and worsening affordability last year and adverse weather this year. Pending home sales had declined for eight consecutive months, although the pace of decline in January and February clearly moderated, suggesting the series was bottoming."<br /></span></span></li>
<li><strong>Don't Miss: <a href="http://www.businessinsider.com/citi-us-top-20-buy-rated-stocks-2014-4">CITI: Here Are The 20 Best Stocks In America »</a></strong></li>
</ul>

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