THEN & NOW: What the stars of 'The 40-Year-Old Virgin' are up to 10 years later

"The 40-Year-Old Virgin" almost didn't happen, but it was a good thing it did, because it helped launch the careers of Hollywood A-listers like Paul Rudd, Seth Rogen, and Steve Carell.

In a recent interview with Conan O'Brien, Carell revealed that the film he helped cowrite with Judd Apatow was almost sacked because Universal felt that Carell looked like a "serial killer" in early footage.

"We hadn't shot any dialogue," he said. "It was me riding my bike with a weird helmet, and it was me walking down the street and seeing suggestive posters and going eghh. And just that week compiled, they went, 'No, no, no, this is not a comedy.'"

But the shooting continued and Apatow's feature directorial debut became a comedic success, leading to "Knocked Up" and more.

Here's what the cast and filmmakers have been up to in the last decade, since "The 40-Year-Old Virgin" came out in 2005: