<p class="ingestion featured-caption">A view of the golf course at The Santa Maria Hotel and Golf Resort in Panama.Punta Pacifica Realty</p><ul class="summary-list"><li>Panama City's wealthy Santa Maria neighborhood is home to the city's only five-star resort.</li><li>The Santa Maria Hotel is known for its Jack Nicklaus-designed golf course and high-end dining.</li></ul><p>The manicured golf course, chlorinated pool, and crisp white tablecloths differed drastically from the <a target="_blank" class href="https://www.businessinsider.com/panama-isla-palenque-private-island-luxury-2024-8">overgrown island I had spent the past three nights on</a>.</p><p>But then again, I was no longer in Panama's Gulf of Chiriqui. I was in Santa Maria, one of <a target="_blank" class href="https://www.businessinsider.com/punta-pacifica-panama-richest-neighborhood-photos-2024-5">Panama City's most expensive neighborhoods</a>.</p><p>And if there's one thing you can expect, it's pristine luxury. To celebrate my final night in Panama, I spent a night at the five-star <a target="_blank" class href="https://affiliate.insider.com?h=28fd95b257051f0f760c6181f0f3b5022bc8964d94ae0bd79e0f0e9bb30f5324&postID=66e9b31bd738168e489d693a&postSlug=panama-santa-maria-resort-jack-nicklaus-golf-course-review-2024-9&site=bi&u=https%3A%2F%2Fwww.marriott.com%2Fen-us%2Fhotels%2Fptylc-the-santa-maria-a-luxury-collection-hotel-and-golf-resort-panama-city%2Foverview%2F">Santa Maria Hotel and Golf Resort</a>.</p>