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This time around, Pee-wee is loving life in his hometown until a mysterious stranger (Joe Manganiello) strolls in one day and inspires Pee-wee to set out on his first-ever holiday.
And as with all of Pee-wee's endeavors, we find him meeting interesting people - like a friendly Amish family - and getting into entertaining situations that might just turn out to be dangerous - like giving female bank robbers a lift.
Watch the trailer below. It launches on Netflix March 18.