In his opening remarks, CBI president Sir Mike Rake outlined the three issues most concerning his members in the run-up to next year's general election.
First, the UK's membership of a reformed European Union is overwhelmingly in our national interest. Eight out of 10 CBI members, large and small, would vote to stay in the EU in a referendum.
Second, 63% of CBI members say that immigration has been beneficial to their businesses; only 1% say it has been negative. The economic evidence shows that immigration is of net benefit.
Finally, falling real wages - a price worth paying to preserve jobs during and after the recession - cannot go on for much longer.
Taken together these points form something of a business manifesto for the major political parties to compete to meet. Yet on all of those three points, the Conservative Party are moving in the opposite direction.
Cameron's speech missed all of the demands of a business community. Right now, there is increased concern over the possibility of losing access to European markets - due to Cameron's pledge to hold a referendum on EU membership in the next parliament - as well as losing access to skilled migrants because of populist immigration controls.
The Prime Minister stressed the need "to do more to control immigration, both outside the European Union and inside the European Union", despite European leaders warning that tighter immigration controls would risk the UK's membership of the economic bloc. He also claimed that the EU referendum wouldn't harm the country's nascent economic recovery.
In response, Labour leader Ed Miliband said that an EU exit would be "a betrayal of our national interest and a clear and present danger to businesses". Even Deputy Prime Minister Nick Clegg, leader of the Liberal Democrats and Cameron's coalition partner, took the opportunity to turn the knife:
"If we can't stand tall in Berlin, Paris, Brussels, how on earth can we stand tall in Washington or Beijing?"
On the plight of British workers, Cameron's barbs also appeared to miss their mark. He took the opportunity to take a swipe at those who claimed that the policies of his government had left people worse off:
"Those who thought the robots would take all the jobs have been proven wrong. Those who thought that the private sector wouldn't be able to offset cuts in the public sector have been proven wrong."
Although he is right that unemployment has fallen rapidly under the current government, this "job well done" narrative grated against the general theme of what needs to be done to fix the country's low wage growth economy.
The CBI's message was clear that business leaders are now one of the groups most concerned about the impact of falling real wages. After all, it is their members that see falling wages impact their profit margins and, ultimately, put a drag on economic activity.
Miliband seized on the theme calling the UK's economic rally a "payless recovery" warning that "millions of people believe that this country is not working for them".
The overriding message is that Britain is in the process of recovering from its economic ailments but it is far from healthy yet. The CBI are prescribing a dose of tax cuts for low-paid families and a reduction in childcare costs to treat the symptoms, alongside long-term treatment of investment in building workforce skills in order to improve competitiveness and productivity.
Although there was a pointed question asked about his support for a return of the 50 pence higher rate of income tax and his support for a mansion tax, Labour's "cost of living crisis" narrative was clearly much closer to the CBI's diagnosis. The Tories, meanwhile, may as well have been prescribing a course of leeches to cure a headache.
Given that the Tories traditionally view themselves as the party of business and enterprise signs that they may have positioned themselves on the wrong side of major issues will be a significant cause for concern in the lead up to the general election. Memories of 1997, where Labour took the enterprise vote from under their noses on the way to a landslide victory, will be fresh in Conservative Party strategists' minds.