TaskRabbit
COO Stacy Brown-Philpot is taking over the position and Busque will become executive chairman.
TaskRabbit, founded in 2008 as one of the first so-called "on-demand" startups, lets people hire temporary workers, nicknamed "rabbits," for chores like moving furniture or house cleaning.
This is the second time Busque has stepped down as CEO. She also took a 9-month break in 2011 and 2012 to concentrate more on product.
Brown-Philpot joined TaskRabbit three years ago after leading global consumer operations at Google. After eight months studying startups as an entrepreneur-in-residence at Google Ventures, she joined TaskRabbit in 2013 to push its business forward - which included some necessary steps like layoffs.
It's a hard job in an environment that has not been friendly to on-demand startups, but Brown-Philpot told Re/code that the company will reach profitability in 2016.