The NSE Nifty dipped 18.10 points or 0.10 per cent to end at 18,297.
Among the Sensex firms, Larsen & Toubro tumbled over 5 per cent after the firm said its Non-Executive Chairman A M Naik has decided to step down from the post.
ITC, Bharti Airtel, Reliance Industries, Infosys, Tata Steel, Tech Mahindra and Tata Consultancy Services were the other laggards.
However, Asian Paints rose the most by 3.22 per cent after it posted a 43.97 per cent growth in consolidated net profit to Rs 1,258.41 crore for the fourth quarter.
Hindustan Unilever, NTPC, IndusInd Bank, UltraTech Cement and Maruti were the gainers.
Vinod Nair, Head of Research at Geojit Financial Services said, "The gains in the domestic market were tempered by weak earnings reported by a few heavyweight companies. On the global front, markets remained positive as US inflation eased below 5 per cent, providing reassurance to investors that the Fed's rate hike measures have been effective in managing inflation levels"
In Asia, Seoul, Shanghai and Hong Kong markets ended lower while Tokyo settled in the green.
Markets in Europe were trading in the green. The US market ended mostly in negative territory on Wednesday.
Foreign Institutional Investors (FIIs) were net buyers on Wednesday as they bought equities worth Rs 1,833.13 crore, according to exchange data.
Meanwhile, global oil benchmark Brent crude jumped 0.93 per cent to USD 77.12 per barrel.
The BSE benchmark had climbed 178.87 points or 0.29 per cent to settle at 61,940.20 points on Wednesday. The Nifty gained 49.15 points or 0.27 per cent to end at 18,315.10 points.
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