The top 12 waiver-wire pickups for Week 16 of fantasy football

ESPN fantasy % rostered: 0.6%

Week 15 stats: 107 rushing yards, 1 reception, 20 receiving yards, 2 touchdowns — 25.7 fantasy points

One thing to know: Duke Johnson came off the Dolphins practice squad to finish the week as the top running back in all of fantasy football on Sunday. Pick him up if you can.

ESPN fantasy % rostered: 44.4%

Week 15 stats: 110 rushing yards, 2 receptions, 9 receiving yards, 1 touchdown — 19.9 fantasy points

One thing to know: Jeff Wilson got 22 carries in the 49ers offense against the Titans and looks to continue to be a huge part of San Francisco's running game even if other members of the backfield start to get healthy.

ESPN fantasy % rostered: 7.3%

Week 15 stats: 7 rushing yards, 4 receptions, 48 receiving yards, 1 touchdown — 15.5 fantasy points

One thing to know: The Panthers have used several players to fill in for Christian McCaffrey since his injury, but Ameer Abdullah is the most involved in the passing game, and thus of the most value to fantasy players in PPR leagues.

ESPN fantasy % rostered: 7.6%

Week 15 stats: 112 rushing yards, 1 reception, 5 receiving yards — 12.7 fantasy points

One thing to know: Craig Reynolds came out of nowhere to help the Lions to victory in relief of several injured running backs ahead of him on the depth chart. Even if D'Andre Swift and Jamaal Williams are back in action in the coming weeks, don't expect Reynolds to be completely shut out from the Detroit rushing attack.

ESPN fantasy % rostered: 8.6%

Week 15 stats: 30 rushing yards, 2 receptions, 13 receiving yards — 6.3 fantasy points

One thing to know: Bengals starting running back Joe Mixon was unable to finish Sunday's game against the Broncos due to injury. If he's out in the coming weeks, Samaje Perine instantly becomes a valuable addition to fantasy rosters.

ESPN fantasy % rostered: 12.6%

Week 15 stats: 5 receptions, 85 receiving yards, 2 touchdowns — 25.5 fantasy points

One thing to know: Gabriel Davis has four touchdowns in his past three games but is somehow still available in nearly 90% of fantasy leagues. With Cole Beasley out for next week's game due after testing positive for COVID-19, Davis will be even more valuable.

ESPN fantasy % rostered: 24.4%

Week 15 stats: 8 receptions, 90 receiving yards, 1 touchdown — 23.5 fantasy points

One thing to know: Amon-Ra St. Brown has gotten a whopping 35 targets over the past three games, likely more than any receiver currently on your active roster. If you need a wide receiver who is going to get some catches, St. Brown is your man.

ESPN fantasy % rostered: 54.6%

Week 15 stats: 8 receptions, 91 receiving yards, 1 touchdown — 23.1 fantasy points

One thing to know: Russell Gage came down with the catch of the season last week, and has been shining bright for what has largely been a disappointing Falcons offense. He's averaging 18.4 fantasy points per game over the last four weeks.

ESPN fantasy % rostered: 15.3%

Week 15 stats: 5 receptions, 98 receiving yards, 1 touchdown — 20.8 fantasy points

One thing to know: Marquez Valdes-Scantling is always a tough guy to trust in fantasy given his boom-or-bust potential. But with the Packers firing on all cylinders right now, it's a good time to buy.

ESPN fantasy % rostered: 47.6%

Week 15 stats: 6 receptions, 77 receiving yards, 2 touchdowns — 25.7 fantasy points

One thing to know: Hunter Henry is a huge part of the Patriots red zone offense. If you need a guy with a shot at scoring twice in a game, he's done it twice in his past four games.

ESPN fantasy % rostered: 2.3%

Week 15 stats: 1 touchdown, 2 interceptions, 1 fumble recovery, 1 safety, 31 points against — 11 fantasy points

One thing to know: Trusting the Jets in the fantasy playoffs won't feel great, but their defense was extremely active against the Dolphins on Sunday, and this week gets a solid matchup against the Jaguars.

Cam Newton (27.1% rostered) hasn't produced great on-field results for the Panthers, but he had a solid game for fantasy players against the Bills on Sunday, scoring 23.3 fantasy points to finish as the fourth-best quarterback in fantasy.

Sam Darnold is set to return from injury, and might be in line to start soon for the Panthers, so don't drop everything just yet to grab Newton. But given the current COVID-19 outbreak taking over the league, it's smart to have a second playable quarterback on your fantasy roster in case your scheduled starter is forced out of action.