Cristiano Ronaldo was left on the bench as Manchester United lost.
Ronaldo didn't look pleased at being put on the bench. Reuters/Toby Meville
Ronaldo missed nearly all of Manchester United's pre-season campaign amid rumors that he wants out of the club.
As such, he was left on the bench for manager Erik ten Hag's first match in charge against Brighton on Sunday, but it proved to be a costly decision.
United found itself 2-0 down at half-time as the club's new central defender Lisandro Martinez struggled and Marcus Rashford failed to make a splash up-top.
Though Ronaldo eventually came on in the second half and helped notably shift the dynamic of the match, it was too little too late as Brighton won the match 2-1 to record a first-ever victory at Old Trafford.
The league's new teams shone, mostly.
Bobby Decordova-Reid, Aleksandar Mitrovic. Getty/Mike Hewitt
Fulham, which was promoted after winning the championship last term, pulled off the result of the weekend as it held Liverpool to a 2-2 draw at Craven Cottage.
Serbian striker Aleksandar Mitrović was the hero on the day, scoring both of Fulham's goals.
Bournemouth, which finished second in the championship last year, also enjoyed a fine return to England's top flight as it beat Aston Villa 2-0.
But Nottingham Forest, which came up through the playoffs, struggled, as Newcastle bested it 2-0.
Chelsea and Tottenham both won.
Chelsea new boy Kalidou Koulibaly had a solid match against Everton. Getty/Chris Brunskill
Both Tottenham and Chelsea made big changes to their squads over the summer and got off to perfect starts as they recorded wins over Southampton and Everton, respectively, on Saturday.
Tottenham swept aside Saints 4-1 thanks to goals from Ryan Sessegnon, Eric Dier, and Dejan Kulusevski, with manager Antonio Conte saying he saw "a lot of positive things" in his team's performance.
Chelsea, playing its first season under its new owner Todd Boehly, didn't quite blow Frank Lampard's Everton out of the water, but a penalty kick from Jorginho was enough to secure a 1-0 win.
Elsewhere over the weekend, Leeds United beat Wolverhampton Wanderers 2-1; Arsenal beat Crystal Palace 2-0; and Leicester City and Brentford saw out a hard-fought 2-2 draw.