10. Air Canada: Toronto (YYZ) - Vancouver (YVR)

The near-2,000 mile nautical route that connects Toronto and Vancouver yielded Air Canada an estimated $541,122,509 during the 12-month period, making the domestic hop Air Canada's highest revenue earning route. The route saw over 45,000 hours of scheduled flight time during that time period, with each hour earning the airline almost $12,000 despite competing with WestJet, Sunwing Airlines, and Flair Airlines.

Air Canada connects two of the country's largest cities with multiple flights per day with aircraft ranging from its smaller Airbus A320 family narrow-bodies to its largest wide-body aircraft including the Boeing 787 Dreamliner, Boeing 777, and Airbus A330. The wide-body aircraft allow for maximum capacity on the route while also catering to business travelers sitting in premium cabins that have access to larger and more private lie-flat seats.