Stanford (-6) over USC
This is a tough pick — you'd much prefer taking Stanford as a three point favorite than the full six here. But I try to pick the biggest games of the week, and this is certainly one of them. Bryce Love was stifled a bit by San Diego State's defense in Week 1, so this is a great spot for him to begin his Heisman campaign in full.
Clemson (-12) over Texas A&M
This is a tough spread but it's hard to imagine the Texas A&M's defense stopping Clemson at any point during this game. The Tigers dropped 48 points against Furman last week without really trying, and will come into this match against the Aggies even more prepared.
Penn State (-8.5) over Pittsburgh
Penn State survived a scare against Appalachian State last weekend, eeking out an overtime win. Admittedly, they didn't look great, but I expect the Nittany Lions to roar back in this spot. Penn State still has memories of Pittsburgh upsetting them in early 2016 in a shootout, and won't be looking to let the Panthers catch them off their game again.
Central Michigan (-4.5) over Kansas
Kansas lost to FCS program Nicholls State in overtime to open the season last week. Head coach David Beaty is in his fourth season with the Jayhawks and holds a record of 3-34. Central Michigan might not strike you as a powerhouse, but they're a regular bowl season competitor and can take care of lesser opponents.
Colorado (+3.5) over Nebraska
I had to take one underdog! Colorado looked solid last weekend in its 45-13 win over Colorado State. Meanwhile, Nebraska's season opener had to be cancelled due to weather concerns. The Scott Frost era will eventually pay off for the Cornhuskers, but give me the team that's already rolling with its season over the one that's been forced to sit on its hands for an extra week.