Larry Page and Sergey Brin brought in a new age of founder control over companies in Silicon Valley. Is their departure a symbol for the end of an era?

A series of scandals rocked Uber in 2017, centering around the leadership of the company's cofounder and CEO, Travis Kalanick

Uber faced a federal criminal probe into whether it used software to illegally evade regulators, widespread allegations of workplace harassment of women and people of color on staff, and a pricey lawsuit from Google over self-driving car technology.

Many of Uber's board members saw Kalanick's leadership as a reason for the conflicts.

He was ultimately ousted by a host of the company's shareholders, including respected venture capital firms like Benchmark, First Round Capital, Lowercase Capital, and Menlo Ventures, The New York Times reported.

Elizabeth Holmes founded blood-testing company Theranos in 2003.

Red flags were raised about her management of the company early on. When two would-be whistleblowers told the board that she exaggerated revenue projections, they considered replacing her with a more experienced manager, according to reporter John Carreyrou, who wrote about the incident in his book "Bad Blood."

But Holmes convinced the board to keep her, and then multiplied her shares to give herself 99% of the company's total voting rights.

Carreyrou investigated Theranos in October 2015 and exposed how the startup, valued at $9 billion, had systematically lied about its technology to both its investors and clients. It had also lied to its employees developing the technology and fired workers who raised their voices in disagreement.

Holmes only stepped down as CEO last summer, and the former CEO faces fraud charges from the Department of Justice. The company dissolved by September 2018.