Companies like Square and Twitter appear to be safe, while the LinkedIn office is just shy of the predicted flood plain.
Pier 39 receives around 11 million annual visitors, while Fisherman's Wharf sees about 12 million per year.
The Millennium Tower already faces structural issues. The tower has sunk 17 inches and tilted 14 inches in the last decade.
By far one of the most devastating consequences of extreme flooding would be damage to the San Francisco International Airport.
The airport serves nearly 56 million passengers a year and employs around 43,000 people. If the area were to be hit by floods, it could have severe economic consequences both inside and outside the Bay Area.