3. Differin Gel

Amazon rating: 4.4 stars out of 6,200+ reviews

Previously only available by prescription, this once-daily topical retinoid works to clear breakouts when they start and prevent new acne from forming. It promotes skin cell turnover and targets clogged pores and inflammation. According to the company, Differin Gel Provided up to 87% reduction in acne lesions after 12 weeks in a clinical study.