Keeping your mouse in the same spot makes you prone to repetitive strain injury

If your mouse stays in the same spot all day, you can be prone to repetitive strain injury (RSI).

Upper-limb RSI occurs when your tendons are straining more than they should for long periods of time, which can be because of movement repetition, a sustained awkward position, or prolonged pressing against hard surfaces.

One option is to use a mouse platform and a forearm support, so you reduce the area you use the mouse in. Another option is to use a shorter keyboard, so you make fewer sideways movements.