REUTERS/Michael Dalder German policemen with machine guns walk away from the Carolinum school in Ansbach near Nuremberg September 17, 2009.
They have reportedly arrested a suspect, who fled by car.
The suspect was reportedly in a silver Mercedes and was shooting from his car, German publication The Local reports.
Police spokeswoman Simone Wiesenberg told n-tv television that the shooter had been arrested but provided no other details.
Earlier, spokesman Bert Rauenbusch told N24 news that a man and a woman had been killed in the morning attack.
At least one other person was wounded.
The killings took place in the southern town of Tiefenthal, near Ansbach. The shooting doesn't appear to be terrorism related, according to German media.