The CDC shortened its COVID-19 isolation recommendation to 5 days for asymptomatic people after some disease experts said 10 days was too long

• People with asymptomatic COVID-19 cases can isolate for just five days, the CDC said Monday.
• Many disease experts had already recommended a shortened isolation period before the announcement.

It was a steadfast rule for most of the pandemic: People with COVID-19 must isolate for 10 days after their symptoms start — or, if they're asymptomatic, for 10 days after their first positive COVID-19 test.

But the Centers for Disease Control and Prevention altered that recommendation on Monday amid a steep rise in Omicron cases across the US. People with COVID-19 who don't have symptoms should isolate for just five days, then wear a mask around others for another five days, the CDC said.

People who've been exposed to COVID-19 should get tested five days after their exposure, the agency said. Those who've received a booster dose should wear a mask for 10 days after an exposure and quarantine if they develop symptoms. People who are unvaccinated or haven't been boosted yet should quarantine for five days after an exposure, then wear a mask for another five days.

The CDC said its decision was motivated by the understanding that most coronavirus transmission "occurs early in the course of illness," generally between one and two days before symptoms arrive and two to three days after a person becomes symptomatic.

Before Monday's announcement, some disease experts had questioned whether the old CDC isolation guidelines were too strict — even for people who develop symptoms.

Five days of isolation, followed by two negative antigen tests (also known as rapid tests), "should be enough to end isolation," Dr. Ashish Jha, the dean of the Brown University School of Public Health, tweeted Sunday.

Jha cited evidence that the average person with COVID-19 probably isn't contagious at least five days after their first positive test (though some people may be contagious for longer or shorter periods of time). Rapid tests are a good proxy for contagiousness, he added, since they're designed to yield positive results when a person's viral load is the highest.

"Having two antigen tests come up negative is a very, very safe way to ensure that you're pretty much outside of your window of infectiousness," Andy Pekosz, a virologist at the Johns Hopkins Bloomberg School of Public Health, told Insider. "One antigen test is good. A second one adds to that level of security and allows you to feel very confident that someone can go back to the workplace without spreading the virus."

Dr. Michael Mina, an epidemiologist at the Harvard T.H. Chan School of Public Health, also suggested Sunday on Twitter that people should be able to test out of isolation after two days of negative tests. The UK allows people to end isolation after seven days after two negative rapid tests taken 24 hours apart.

For those without access to rapid tests, a week of isolation may still be sufficient, some experts told Insider before the CDC released its new recommendation.

"Seven to 10 days is probably a fair estimate if you're not going to be able to confirm your testing status in a reasonable amount of time," Pekosz said, adding: "A 10-day isolation probably errs on the side of being overly cautious."

Isolation time may also depend on symptoms and vaccination status

The CDC adjusted its isolation guidelines for healthcare workers last week. Healthcare workers with COVID-19 can return to work after seven days if they're asymptomatic and test negative, the agency said.

The New York State Department of Health also said last week that fully vaccinated essential workers, including healthcare professionals, could end their isolation after five days if they were asymptomatic or their mild symptoms were improving and they didn't have a runny nose. In that case, essential workers don't have to test negative to end their isolation, the department said.

Waning symptoms, Pekosz said, are usually a sign that a person is becoming less contagious — but symptoms aren't the sole indicator of whether a person with COVID-19 can infect others.

"We should actually rely more on the antigen-test results rather than on the symptoms," Juliet Morrison, a virologist at the University of California, Riverside, told Insider. "Having symptoms means that you are likely infectious, but we know that there are lots of asymptomatic infections, as well as presymptomatic infections, and that we can still get transmission in that scenario."

She added that isolation guidelines should also consider a person's vaccination status. Morrison said there was a case to be made for shortening the isolation period to five days with two negative antigen tests for vaccinated people.

"From a scientific standpoint, it absolutely makes sense that somebody who is vaccinated would be clearing the virus more quickly than somebody who is unvaccinated," she said, adding: "People do have to support their families, so if five days is enough, we shouldn't be insisting on 10 or seven."

Some experts are still wary of how rapid tests perform against Omicron

Rapid tests are more reliable than a PCR when it comes to determining if you're contagious.

"If you're trying to test yourself out of isolation, you don't want a PCR test because they will give you a positive far out beyond when you are actually contagious," Morrison said.

But experts say rapid tests aren't foolproof.

"I always get nervous when we're using testing to declare somebody as safe," Susan Butler-Wu, an associate professor of clinical pathology at the University of Southern California, said.

"Not all antigen tests behave identically," she added. "Each brand works slightly differently in terms of how it's designed and has a slightly different what we would call 'limit of detection,' meaning how much virus has to be there for me to be able to detect it."

Butler-Wu said she wouldn't feel comfortable isolating for fewer than 10 days with COVID-19. Scientists are still studying how well rapid tests detect Omicron and how long people with the variant are capable of infecting others, she said.

"Omicron is new. We know it's more transmissible, but we don't know as much about it," Morrison added. "So the 10-day isolation period might be too short, but it might also just be perfect."