+

Cookies on the Business Insider India website

Business Insider India has updated its Privacy and Cookie policy. We use cookies to ensure that we give you the better experience on our website. If you continue without changing your settings, we\'ll assume that you are happy to receive all cookies on the Business Insider India website. However, you can change your cookie setting at any time by clicking on our Cookie Policy at any time. You can also see our Privacy Policy.

Close
HomeQuizzoneWhatsappShare Flash Reads
 

One striking chart shows just how well Pfizer's vaccine works to prevent COVID-19 infections

Dec 9, 2020, 02:01 IST
Business Insider
ACOB KING/POOL/AFP via Getty Images
  • The Food and Drug Administration released data about Pfizer's coronavirus vaccine on Tuesday.
  • The data suggests the company's two-shot course works very well to prevent COVID-19 infections.
  • One chart in the brief suggests that protection begins 14 days after a person's first shot and gets much better after their second shot.
Advertisement

The US Food and Drug Administration released safety and efficacy data on Pfizer's novel coronavirus vaccine on Tuesday - and it's looking good.

In a 53-page briefing document posted on its website, the FDA said data indicated that Pfizer's mRNA vaccination course worked well in thousands of people of various ages, races, and sexes who tested it in six countries.

One chart in the briefing materials documented how many people during the study got COVID-19, the disease caused by the novel coronavirus. Comparing those who got the Pfizer vaccine with those in the control group shows just how well the two-shot vaccine course worked to prevent infections.

The red line in the chart represents how many of the roughly 21,000 participants in the control group - those who (unknowingly) received a bogus (placebo) shot - got sick. The blue line shows the COVID-19 infection rate among the roughly 21,000 people who received the real Pfizer shot.

COVID-19 infections in the placebo group went up and up and up during the study, while people who got the vaccine were well protected from infection, in almost all cases.FDA / Pfizer-BioNTech COVID-19 Vaccine VRBPAC Briefing Document

The chart suggests people who got the real Pfizer vaccine started to gain protection from infection 14 days after their first shot.

Advertisement

Then, 21 days in, they got their second (and final) shot. After that, they were well protected from infection for at least two more months.

It's possible the vaccine's protection lasts much longer than that - it's just too soon to know for sure.

The most common side effects for vaccine-takers included: pain at the injection site (84%), fatigue (65%), and headaches (55%). Less common vaccine side effects were: muscle aches (38%), chills (34%), joint pain (24%), and fever (14%).

Reports of side effects were more common in younger study participants (under 55 years old), and typically lasted just a day or two, generally appearing within a couple of days of vaccination.

The vaccine's protection got a lot better with the 2nd shot

A 16-year-old participates in Pfizer's clinical trial to test its coronavirus vaccine candidate. She was the first adolescent patient at Cincinnati Children’s Hospital to enroll in the study.Cincinnati Children’s Hospital

It takes some time for shots to take effect in the body, providing robust and full protection against the virus. Several became sick with COVID-19 after getting the first Pfizer shot but before receiving their second shot.

Advertisement

But starting one week after the second shot, the vaccine was much more effective at preventing infections. The 2-shot course had a vaccine efficacy of 95%.

"This is super exciting," Deborah Fuller, a vaccine expert from the University of Washington who was not associated with the Pfizer trial or the FDA's review of it, told Business Insider. "To be already out the door right away with 90-something percent, that's as good as any vaccine out there that we can get."

Only eight people got COVID-19 after receiving both doses of the Pfizer vaccine and waiting a full week for the vaccination to take effect (roughly 28 days from the start of the trial). Only one person among those eight suffered a severe case of the disease; they were not hospitalized.

Meanwhile, in the control group with no protection, cases climbed. After day 28, the group recorded more than 160 infections, with three severe cases, including two hospital admissions (one in the intensive-care unit).

The FDA is scheduled to hold an advisory committee meeting on Thursday to help decide whether the agency will approve - or reject - what would be America's first emergency-authorized COVID-19 vaccine. Pfizer's vaccine has already been approved for use in the UK and Bahrain.

Advertisement
You are subscribed to notifications!
Looks like you've blocked notifications!
Next Article