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It was the first time the Patriots have been shut out since 2006, and the first time they've been shut out at home since 1993.
It all went wrong for the Patriots, who, behind rookie quarterback Jacoby Brissett, couldn't get their offense going throughout the entire game.
Afterward, Bills coach Rex Ryan seemed to have some fun at the Patriots' expense. In his postgame interview, he seemingly mocked the last-minute decision by the Patriots to start Brissett over Jimmy Garoppolo, who is still injured.
"My sources inside the Patriots building told me Jacoby Brissett would be the QB," Ryan quipped. "How about that? I'll stir some stuff up."
Ryan appears to have thought the Patriots were trying to throw off the Bills by not revealing their starting quarterback until right before the tip-off. Ryan also said he wasn't too concerned with whoever was running the offense for the Patriots, saying the Bills "expected" a win because neither Garoppolo or Brissett are as good as Tom Brady.
The importance of the win can't be understated for the Bills. They're now 2-2 going into a Week 5 game against the Los Angeles Rams. After dropping their first two games, the Bills looked like they were in danger of going 0-4 to start the year, with matchups with the Arizona Cardinals and Patriots ahead. Instead, they won both games and now sit second in the AFC East behind the 3-1 Patriots. The win also gives them a one-game lead over the New York Jets, who fell to 1-3 on Sunday.
Who knows if Ryan actually has sources inside the Patriots or if he wants to taunt them over the win (not to mention theories about the Patriots' locker rooms). But nobody in the NFL enjoys a win over Bill Belichick more than Rex Ryan.