In a statement from Kensington Palace, the Prince expressed his view that "a line has been crossed" in press coverage and social media trolling of Markle.
The statement said Prince Harry was concerned for his partner's safety and hopes that the press will "pause and reflect" before any further damage is done.
His spokesman was critical of the "racial undertones" in the media coverage, while he lambasted the "outright sexism and racism of social media trolls and web article comments."
More follows.
Kensington Palace has issued a statement this morning about the harassment currently being experienced by Meghan Markle and her family. pic.twitter.com/EuFZ4fmUIj
- Kensington Palace (@KensingtonRoyal) November 8, 2016