The development came shortly after the Bombay High Court directed the CBI to conduct a preliminary inquiry within 15 days into allegations of corruption and misconduct levelled by former Mumbai police chief Param Bir Singh against him.
"Deshmukh informed NCP chief Sharad Pawar that it won't be appropriate to remain in the post as CBI will be probing the charges against him," senior party minister
Deshmukh submitted his resignation letter to Thackeray, Malik said.
State BJP chief Chandrakant Patil said he is happy that Deshmukh has quit, adding there will be many "shocking revelations" in the CBI probe.
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