Jeff Swensen/Getty Images
Ryan, the highest-ranking elected Republican, said the brutal primary season offered "signs of life" inside the GOP.
"Democracy is a series of choices," he said. "We Republicans have made our choice."
The Wisconsin Republican contrasted the GOP nominee, Donald Trump, with the presumptive Democratic nominee, Hillary Clinton.
"They are offering you a third Obama term brought to you by another Clinton," he said. "And you're supposed to be excited about it."
He later added: "2016 is the year America moves on."
Ryan concluded that "only with Donald Trump and Mike Pence do we have a chance of a better way."