Orlando police
Orlando police confirmed that multiple people had been injured and urged people to stay away from the area.
The gunman entered Pulse at approximately 2am local time armed with an assault rifle.
On its Facebook page, the nightclub said: "Everyone get out of pulse and keep running."
A witness told Sky News that more than 100 people were in the club. "We just heard shots, it was less than a minute, it felt longer," he said.
Local news anchor Stewart Moore tweeted saying more than 20 people have been shot, and that the attacker may have been wearing a bomb, although this has not been confirmed.
shots being fired outside of #PulseOrlando #PulseShooting. (Via Anthony Torres on Facebook, https://t.co/uIlW1M1rl0) pic.twitter.com/pVXOec1eZx
This is a breaking news story and will be updated as more information comes in.