You can choose from more than a dozen different playable characters.
As you progress through the game you'll have the chance to unlock new agents by finding their DNA hidden within New Providence. Each character has their own back story and specific perks that affect their stats, but your choice of agent wont really change how the game plays. While the playable agents have occasional quips during the game, their comments don't add much that fleshes out the personality of the characters or the ongoing story of the game.