Meaningless touchdown provides a miracle backdoor cover at the end of 'Monday Night Football' for the second time in 3 weeks

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Just two weeks after the Chiefs miracle cover on the final play of "Monday Night Football," football bettors' hearts were broken yet again, this time by the Tennessee Titans.

Heading into the game, the Titans were favored by 7.5 points.

With a minute remaining in the game, People who had bet on the Colts were likely already counting their winnings. The Titans had the ball with a seven-point lead, and only needed one more first down before they could line up in victory formation to win by a final score of 29-22. Colts bettors would have won by half a point.

But on third-and-five from the Titans' own 27-yard line, running back Derrick Henry had other ideas. He broke free for a 73-yard touchdown that sealed the game for Titans fans and Titans bettors alike.

The run was especially devastating because once Henry had crossed the first-down marker, the Titans' victory had already been secured. But rather than go down with the ball, Henry broke for the end zone and likely switched the fortunes of quite a few fantasy football matchups in addition to hundreds of thousands of dollars in Vegas.

The run lead to strong reactions from gamblers on Twitter, many of whom, it seemed, had backed the Titans.

Still, there were those on the other side of the bet that were less than thrilled with the result.

The lesson, as always, is that gambling is a cruel mistress.