Pilots have gone on a 24-hour flights and it will start at midnight and affect
Out of the roughly 3,000 planned short- and long-haul flights, 876 will be cancelled due to the strike, "affecting some 100,000 passengers", Lufthansa said in a statement.
It will be the union's 14th strike since April 2014.
In the meantime, a separate walkout by cabin crew at Lufthansa's low-cost airline Eurowings led to the cancellation of more than 60 flights at airports in Hamburg and Duesseldorf.
The industrial action was called by Germany's biggest services union Verdi in a row over pay and working conditions.
The pilots are demanding a pay rise of an average of 3.66 percent per year, retroactive for the past five years.