REUTERS/Larry Downing
Potential questions include the recent frostiness with Vladimir Putin and Russia following the cancellation of a meeting earlier this week.
He'll likely also be asked about ongoing developments in the story about National Security Agency surveillance of Americans' communications.
We'll likely hear about the major fiscal fights currently pending in Congress: the need to pass a continuing resolution to keep funding the government past September 30, and to raise the debt ceiling which the federal government will likely hit sometime in the fall.
And Obama may face questions about whom he will appoint to be the next chairperson of the Federal Reserve.
We'll have live updates here.