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But Spieth won't be the only player vying for the Wanamaker Trophy. Dozens of other talented golfers are also in the Tar Heel state, and they all have the same goal: getting a taste of major glory before the year is out.
The course, Quail Hollow, is getting its first shot at a major after years of hosting the PGA Tour's Wells Fargo Championship. While most PGA Tour regulars are familiar with the track, it did undergo some significant renovations in preparation for this week, including new bermudagrass, the removal of hundreds of trees and some new and redesigned holes.
Given those changes, as well as some dicey weather in the weekend forecast, anything can happen this week. Here are ten players who could spoil Spieth's shot at nabbing the career Grand Slam in 2017.