Her rom-com blockbusters "Along Came Polly" and "Bruce Almighty" performed well with critics and in theaters. The latter, headlined by Jim Carrey, raked in $484 million worldwide.
Then an unfortunate string of flops began — enough to earn Aniston the label "box office poison."
Her latest movie, "We're the Millers," about a group of misfits who pose as an all-American family to move a large shipment of marijuana into the U.S., may give Aniston's movie career the second wind it needs.
Co-starring Jason Sudeikis, Emma Roberts, and Ed Helms, "
Here are the misses that led up to Aniston's "We're the Millers" redemption.