REUTERS/Stefano Rellandini
The move comes at a pivotal moment for the Italian banking sector, which is weighed down with bad debt and low profitability and buffeted by political instability.
The bank, Italy's biggest will make the cuts over two years and will aim to boost its capital ratio - a measure of financial strength - and pay investors a dividend by 2019.
The lender plans shut down around a quarter of its 3,800 branches, while the 14,000 job losses represent around 11% of the lender's total staff.
Chief executive Jean Pierre Mustier said it was a "pragmatic plan based on conservative assumptions, with tangible and achievable targets," according to a BBC report.
The Italian banking crisis is coming to a head after the resignation of former Prime Minister Matteo Renzi last week. Banca Monte dei Paschi, the world's oldest lender and Italy's third-biggest bank, is attempting to raise €5 billion by the end of the year to stay in business.
The sector is carrying more than €300 billion in non-performing loans and may ultimately need an injection of around €52 billion, according to Deutsche Bank analyst Paola Sabbione.
Renzi resigned after losing a referendum aimed at restructuring the Italian parliament.
Mustier told the Financial Times: 'The referendum was a No but it doesn't change our business model. The Monte dei Paschi situation will be solved, and by the year-end. There will be no overhang from Monte dei Paschi."
Here is what happened to Unicredit shares on the news:
Investing