Vice President Delcy Rodriguez said Saturday that the 45 new cases bring Venezuela's total to 504 illnesses, with 10 resulting in death.
Officials have reported a relatively low number of cases since the first were discovered in mid-March.
While Venezuela has reported relatively few cases so far, health experts say its hospitals are especially vulnerable to being overwhelmed.
Venezuela is in a deep political and economic crisis that has left its health care system in a shamble.
President Nicolás Maduro ordered a nationwide lockdown shortly after the first cases, and he recently extended it until mid-June, hoping to contain the virus' spread.
Officials say that 35 of Saturday's cases involved people returning to Venezuela, including several on a flight from Peru. (AP) INDIND