According to a report in NHK,
The development comes after Abe's visit to a Tokyp hospital twice over the past two weeks, fuelling speculation that his health has deteriorated.
This is the second time that the Prime Minister will step down from his post over a medical issue.
He resigned in 2007 because of an inflammatory bowel disease, after only serving a year in office.
He returned to the top job in 2012 after a landslide election win in the Lower House.