At least 2 people were killed and 2 injured after a small plane crashed into a Southern California neighborhood

• Multiple fatalities were reported after a small plane crashed in a Southern California neighborhood.
• The plane struck two homes and a UPS delivery truck, local officials wrote on Twitter.

Multiple fatalities and injuries were reported after a small plane crashed into a neighborhood in Southern California, authorities said Monday.

The Cessna 340A plane crashed shortly afer 12 p.m. local time in the city of Santee, California, on Greencastle Street and Jeremy Street, roughly 20 miles northeast of San Diego.

The plane was headed to San Diego from Yuma, Arizona, officials said, but an issue on the plane prompted the pilot to attempt to land at Gillespie Field in El Cajon, California, less than five miles away from the crash site, officials said, according to a report by NBC7.

Speaking to reporters, an official with the Santee Fire Department said the crash had caused several homes and vehicles to catch fire, NBC7 reported.

"As far as any of the cause of the aircraft crashing, that's still to be determined," Deputy Fire Chief Justin Matsushita said. He said there were at least two confirmed deaths. It is not yet clear how many people were on the plane. Matsushita described their injuries as "non-survivable."

"Not to be too graphic, but it's a pretty brutal scene," he said.

The incident occurred a few blocks away from Santana High School. School officials said all of its students are safe and are being released for dismissal.

The plane struck two homes and a UPS delivery truck, local officials wrote on Twitter. Photos of the incident show the two homes engulfed in flames and plumes of smoke billowing into the sky.

Officials said at least two people were killed in the incident, one of whom was the UPS driver struck by the plane, NBC7 reported. Two people with burn injuries were also taken to the hospital for treatment, Fire Chief John Garlow told USA Today. It is unclear if those those who were injured were among the dead.

Officials from the Federal Aviation Administration said they, along with the National Transportation Safety Board, will investigate the incident.

"The NTSB will be in charge of the investigation and will provide additional updates," the FAA said in a statement, citing a report by CNN. "Neither agency identifies people involved in aircraft accidents."

Garlow said the city of Santee has seen other plane crashes in the past. There was another fatal plane crash in Santee in 2015, about four miles away from the crash site on Monday. Another plane crash in the area also killed the pilot 10 years ago, Garlow said, USA Today reported.