The cause of the death was "acute respiratory distress syndrome", he said.
"Regret to report the death of a COVID positive 55- year-old male of Ganjam (district), while under treatment in hospital," the Health and Family Welfare Department said in a statement.
The state also recorded 112 new cases, including 21 disaster response personnel who were engaged in cyclone Amphan restoration work in West Bengal.
Odisha now has a total of 3,498 COVID-19 cases of which 1,131 are active, while 2,354 patients have so far recovered from the disease. COVID-19 has claimed 10 lives in the state so far.
As many as 107 of the fresh cases were reported from quarantine centres for returnees, officials said. AAM RBT DV DV