Using the Economic Policy Institute's family budget calculator, which accounts for two parents and two kids, research engine FindTheHome created a cost of living index to compare over 600 US metros.
They then analyzed the data in 15 major cities to determine a suggested take-home household income to live comfortably in each area using the "50-30-20 rule" of personal finance, meaning 50% of after-tax, take-home pay goes to necessities (such as housing, food, childcare, healthcare, and transportation), 30% towards discretionary spending, and 20% towards saving.
Note that these numbers are suggestions based on the available data. They are meant for a four-person family and suggest a generous amount of annual savings, which may not be preferred or possible for some families.
Scroll down to see the suggested take-home income for 15 major US metro areas, plus the estimated annual cost of necessities, discretionary spending, and optimum savings.