Expectations are for the reading to come in at 58.0, down from last month's 59.0 reading, which blew away expectations.
The prices paid sub-index of ISM's report is expected to come in at 52.1, down from 53.5 in October.
The latest report also comes just after Markit's manufacturing PMI report, so a busy morning for data on the US manufacturing sector.
We'll be back with the live numbers when they hit.