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In addition to Smith, who was shot several times, his wife was also shot twice in the leg and has been hospitalized, according to NBC News.
New Orleans Police said Smith's car was rear-ended by a Hummer and then his Mercedes hit a third car.
According to a police statement, "the male victim and the driver of the Hummer exchanged words at which time the driver of the Hummer produced a handgun and shot the male victim multiple times."
"It appears that it could possibly have been road rage," Officer Juan D. Barnes Sr. told a press conference.
A suspect is in police custody, and according to the reports, a gun has been recovered.
The Saints released a statement, calling the incident "a senseless and tragic loss."
A senseless and tragic loss. Our thoughts and prayers are with Will Smith - his wife Racquel - his children William, Wynter and Lisa.
- Greg Bensel (@GregBensel) April 10, 2016