What the star-studded cast of Netflix's 'Big Mouth' looks like in real life

"Big Mouth," Netflix's hit animated series following a group of teenagers as they go through puberty, was created by Nick Kroll, his childhood best friend Andrew Goldberg and married screenwriting team Jennifer Flackett and Mark Levin.

In addition to his behind-the-scenes role, Kroll also stars in the show as several key characters. He voices the lead Nick Birch, a boy who is adapting to puberty. Kroll also plays two other human characters – Lola Skumpy, a mean popular girl from Nick's school and Coach Steve, a scatterbrain, incompetent sports teacher at Nick's school.

In the "Big Mouth" world, hormones, feelings, and mental illness are personified through monsters, animals, and other creatures. Kroll voices two significant Hormone Monsters, creatures who guide people through the ups and down of puberty.

Kroll plays the horny Hormone Monster Maury, who is the guide for Nick's best friend Andrew, and Rick, a really old Hormone Monster.

Outside of "Big Mouth," Kroll's notable career achievements include creating the series' spinoff Netflix show "Human Resources," starring in "Don't Worry Darling," and appearing in other popular comedies such as "Sausage Party" and "Sing."

Nick Birch is joined on his adventure through puberty by his best friend Andrew Glouberman, who is obsessed with masturbation at the beginning of the show.

He is voiced by popular comedian John Mulaney, a former "Saturday Night Live" writer who has also previously had voice roles in "Puss in Boots: The Last Wish" and "Spider-Man: Into the Spider-Verse."

Jessi Klein plays Jessi Glaser, a close friend of Nick and Andrew, who explores her sexuality and struggles with depression during the series.

Klein is best known for her writing and producing work, having previously produced "Inside Amy Schumer," "Transparent," and "Dead to Me."

Missy is a biracial nerdy classmate of Andrew, Jessi, and Nick.

In the first four seasons, Missy was voiced by Jenny Slate. However, amid the discussions of racism in America in 2020, Slate stepped down from the role and apologized for previous racist behavior.

Slate was replaced with Ayo Edebiri, as Missy began to explore her Black identity. At the time, Edebiri mainly had writing credits to her name but she has since become more well-known for her on-screen roles in "Dickinson," "Bottoms," "The Bear," and "Teenage Mutant Ninja Turtles: Mutant Mayhem."

Jay Bilzerian is another friend of Andrew, Nick, and Jess. He is sex-obsessed and discovers he is bisexual halfway through the show.

Bilzerian is played by Jason Mantzoukas, who has previously played equally wacky characters in "Brooklyn Nine-Nine" and "The Good Place."

Matthew MacDell was a secondary character in the first few seasons. But the openly gay, gossiping student has become one of the main characters in recent seasons.

He is voiced by Andrew Rannells. Rannells, who is better known for his Broadway career, has starred previously in "The Prom," "Girls" and "The Boys in the Band." He also has a vibrant voice-acting career, appearing in shows such as "Sonic X," "Pokémon," and "Invincible."

Connie LaCienega is the main Hormone Monstress for Jessi and also has a relationship with Maury.

She is played by Maya Rudolph, who rose to fame during her time on the cast of "Saturday Night Live." Rudolph has won four primetime Emmys and starred in numerous movies and TV shows including "Bridesmaids," "The Mitchells vs the Machines," and "The Lego Movie 2."

One of Nick's friends is the ghost of Jazz pianist Duke Ellington, who lives in the teen's attic.

He is voiced by Jordan Peele, the Oscar-winning horror director and comedy actor. Peele is best known as the filmmaker behind "Get Out," "Nope," and "Us" but he also starred in "Toy Story 4" and his own comedy show "Key and Peele."

When Missy goes through puberty, she is somehow stuck with the British Hormone Monster Mona.

Thandiwe Newton plays the character. Newton is known for her roles in "Westworld," "Mission Impossible II" and "Solo: A Star Wars Story."

Elijah is a religious Christian kid who was first introduced in season six and is now in a relationship with Missy.

He is voiced by Brian Tyree Henry, who is known for his roles in "Atlanta," "Bullet Train" and Marvel's "Eternals."

Henry also has voice acting experience from starring in the "Spider-Verse" movies as Miles Morales' father Jefferson.

Netflix announced in the first teasers for season seven that "WAP" rapper Megan Thee Stallion will appear in the show as her very own Hormone Monstress. Later trailers imply she is the Hormone Monstress for a new human character, Danni.

Megan Thee Stallion is better known for her rapping career, although she's recently had acting roles in Disney+'s "She-Hulk: Attorney At Law" show and movies such as "Dicks: The Musical."

New season seven character Danni is a student at a private school that Nick is considering attending. The pair bond while he visits the school.

Danni is played by Zazie Beetz. Beetz is known for her roles in "Atlanta," "Deadpool 2," "Joker," and "Bullet Train."

Ahead of the premiere, Netflix revealed that Billy Porter would also be playing a new character in season seven. Porter's character, Ocean, leads the Queer Choir at the main school, Bridgerton High.

Porter, a Broadway performer and actor, was the first openly gay Black man to win an Emmy. He took home the award for his role in FX's "Pose."

Ahead of the premiere, Netflix revealed that Lin-Manuel Miranda had written an original song for the show and seems to be playing a piece of pubic hair.

Miranda is best known for creating the hit Broadway show "Hamilton" but has also written "Encanto," "In The Heights," and directed "Tick, tick.... BOOM!" The Oscar-nominated actor has also been in front of the camera in "Mary Poppins Returns," "How I Met Your Mother" and "His Dark Materials."