<p class="ingestion featured-caption">Avantika Vandanapu as Karen Shetty, Angourie Rice as Cady Heron, Reneé Rapp as Regina George, and Bebe Wood as Gretchen Wieners in "Mean Girls."Jojo Whilden/Paramount</p><ul class="summary-list"><li>Warning: There are major spoilers ahead for the new "Mean Girls" remake, now playing in theaters. </li><li>The musical movie retains the same major storyline as the 2004 film but makes some changes.</li></ul><p>"<a target="_blank" href="https://www.businessinsider.com/mean-girls-musical-movie-cast-characters-new-vs-old-2024-1">Mean Girls</a>" has been revived for a new generation with a <a target="_blank" href="https://www.businessinsider.com/mean-girls-2024-remake-cast-real-ages-versus-characters-2024-1">new cast</a> of shiny Plastics.</p><p>Despite the marketing, the film is a full-on musical, inspired by the "Mean Girls" Broadway play that opened in 2018.</p><p>The remake stars Angourie Rice as Cady Heron, <a target="_blank" rel href="https://www.businessinsider.com/renee-rapp-too-well-sex-lives-mean-girls-interview-2023-4"><u>Reneé Rapp</u></a> as Regina George, and Christopher Briney as Aaron Samuels. The movie follows the same overall plot as the 2004 movie that starred <a target="_blank" href="https://www.businessinsider.com/mean-girls-where-are-they-now-2017-10">Lindsay Lohan</a>, but there are some changes — aside from the addition of musical numbers.</p><p>Here are the biggest differences between the 2004 and 2024 versions of "Mean Girls."</p>