The 13 most famous brother and sister duos in Hollywood

This dancing duo is best known for their time spent on ABC's "Dancing With the Stars," though they've both appeared in other notable projects. Julianne Hough starred in the 2011 remake of "Footloose," while Derek has appeared on multiple episodes of ABC's "Nashville," and has guest-starred on "Jane the Virgin."

Both of these siblings' acting careers go way back, but you most likely recognize Jussie Smollett from his role as Jamal Lyon on Fox's hit series "Empire," and Jurnee Smollett from HBO's new sci-fi drama "Lovecraft Country."

Jurnee's long career in Hollywood also includes the DC movie "Birds of Prey," and classic sitcoms like "Full House" and "Hangin' With Mr. Cooper."

Jussie and Jurnee appeared on the WGN's "Underground" together last year.

Shirley Maclaine is a six-time Academy Award nominee who won best actress for 1984's "Terms of Endearment." Once she got into acting her younger brother, Warren Beatty, quickly followed in her footsteps.

Beatty has been nominated for 14 Academy Awards — four for best actor, four for best picture, two for best director, three for original screenplay, and one for adapted screenplay — winning best director for "Reds" in 1981. He's also been nominated for 18 Golden Globe Awards, of which he won six.

Both Maggie and Jake Gyllenhaal have received Academy Award nominations, not to mention that they come from an equally talented family — their father is director Stephen Gyllenhaal ("Family of Spies," "Numb3rs"), and their mother is screenwriter Naomi Foner.

Jake Gyllenhaal joined the Marvel Cinematic Universe in 2019 when he played a villain in "Spider-Man: Far From Home." Maggie Gyllenhaal recently starred in HBO's drama series "The Deuce."

For much of the '90s, Julia Roberts was the world's highest-paid actress thanks to roles in iconic films such as "Pretty Woman" and "Sleeping With the Enemy." But her older brother Eric also has a few accomplishments under his belt.

Eric Roberts has received multiple Golden Globe nominations, and was nominated for an Academy Award for his work in 1985's "Runaway Train."

We'll make an exception for this talented trio. The Mowrys have been acting since childhood, with Tia and Tamera best known for playing twins who were reunited after being separated at birth on "Sister, Sister."

Tahj played Teddy on "Full House" before moving on to star as a kid genius in Disney's "Smart Guy." The siblings also appeared together in the 2002 film "Seventeen Again."

Brandy was topping multiple charts as an R&B singer back in the '90s before landing the starring role on the UPN-produced sitcom "Moesha." Soon after "Moesha" took off, her younger brother Ray J joined the cast as Brandy's on-screen brother.

Along with their parents, the two also appeared in their own VH1 reality series in 2010 called "Brandy and Ray J: A Family Business."

Peter and Jane Fonda are practically Hollywood royalty. They were clearly destined for stardom seeing as their father, Henry Fonda, was also a well-known actor. After getting into theater at an early age, Jane Fonda is now a two-time Academy Award-winning actress, while her younger brother is also Oscar-nominated.

The Cusacks aren't afraid to show their love for each other on-screen. The siblings have starred in more movies together than any other celebrity siblings, as they've shared the screen a whopping 10 times, from "Sixteen Candles" to "Grosse Pointe Blank" to "War, Inc."

Another talented family, Tracee Ellis Ross is known for her role as Rainbow Johnson on ABC's "black-ish," while her younger brother Evan Ross starred alongside rapper T.I. in the 2006 film "ATL." Their mother? None other than singer Diana Ross.

Both actors were popular sitcom stars in the '80s, with Justine playing Mallory Keaton on "Family Ties" until 1989, and Jason becoming a teen heartthrob as David Hogan on "The Hogan Family." Since then, Jason has appeared on "Arrested Development," while Justine recently earned a degree from UCLA in 2016.

Virginia Madsen got her start in the '80s thanks to David Lynch's "Dune," and her career continued throughout the '90s and was cast on the first season of ABC's 2016 drama "Designated Survivor."

You'll recognize Michael Madsen, who also has an illustrious film career, including "Reservoir Dogs" and "Kill Bill."

David Arquette is a successful Hollywood producer and actor, best known for his roles in the iconic '90s "Scream" franchise and "Never Been Kissed." Patricia made her movie debut at age 18 in "A Nightmare on Elm Street 3," and performed in dozens of subsequent films. In 2014 she won the Academy Award for best supporting actress for her role in Richard Linklater's "Boyhood."