The auction features a mix of electric, bass and acoustic guitars taken from his personal collection.
All items have been signed by the 46-year-old musician and come with a letter of authenticity.
"Bid on 13 used and signed guitars I'm auctioning off to benefit @DirectRelief's COVID-19 efforts. Every guitar comes with a case and COA. Let's help @DirectRelief provide PPE and essentials to healthcare workers," Taylor tweeted.
The money raised from the sale of the instruments will go directly to Direct Relief, a not-for-profit charity that provides global financial relief to people affected by disease, poverty and natural disaster.
The sale is live now on eBay and will run through May 7.
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